Thalamocortical bursts trigger recurrent activity in neocortical networks

Layer 4 as a frequency-dependent gate

Michae L. Beierlein, Christopher P. Fall, John Rinzel, Rafael Yuste

Research output: Contribution to journalArticle

Abstract

Sensory information reaches the cortex via thalamocortical (TC) synapses in layer 4. Thalamic relay neurons that mediate information flow to cortex operate in two distinct modes, tonic and burst firing. Burst firing has been implicated in enhancing reliability of information flow between individual neurons. However, little is known about how local networks of neocortical neurons respond to different temporal patterns of TC activity. We studied cortical activity patterns evoked by stimulating TC afferents at different frequencies, using a combination of electrophysiology and calcium imaging in TC slices that allowed for the reconstruction of spatiotemporal activity with single-cell resolution. Stimulation of TC axons at low frequencies triggered action potentials in only a small number of layer 4 neurons. In contrast, brief high-frequency stimulus trains triggered widespread recurrent activity in populations of neurons in layer 4 and then spread into adjacent layers 2/3 and 5. Recurrent activity had a clear threshold, typically lasted 300 msec, and could be evoked repetitively at frequencies up to 0.5 Hz. Moreover, the spatial extent of recurrent activity was controlled by the TC pattern of activity. Recurrent activity triggered within the highly interconnected networks of layer 4 might act to selectively amplify and redistribute transient high-frequency TC inputs, filter out low-frequency inputs, and temporarily preserve a record of past sensory activity.

Original languageEnglish (US)
Pages (from-to)9885-9894
Number of pages10
JournalJournal of Neuroscience
Volume22
Issue number22
StatePublished - Nov 15 2002

Fingerprint

Neurons
Electrophysiology
Synapses
Action Potentials
Axons
Calcium
Population

Keywords

  • Barrel cortex
  • Feedforward inhibition
  • Fura-2
  • NMDA
  • Persistent activity
  • Temporal summation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Thalamocortical bursts trigger recurrent activity in neocortical networks : Layer 4 as a frequency-dependent gate. / Beierlein, Michae L.; Fall, Christopher P.; Rinzel, John; Yuste, Rafael.

In: Journal of Neuroscience, Vol. 22, No. 22, 15.11.2002, p. 9885-9894.

Research output: Contribution to journalArticle

Beierlein, Michae L. ; Fall, Christopher P. ; Rinzel, John ; Yuste, Rafael. / Thalamocortical bursts trigger recurrent activity in neocortical networks : Layer 4 as a frequency-dependent gate. In: Journal of Neuroscience. 2002 ; Vol. 22, No. 22. pp. 9885-9894.
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