TGFBR1*6A may contribute to hereditary colorectal cancer

Yansong Bian, Trinidad Caldes, Juul Wijnen, Patrick Franken, Hans Vasen, Virginia Kaklamani, Khédoudja Nafa, Paolo Peterlongo, Nathan Ellis, John A. Baron, John Burn, Gabriela Moeslein, Patrick J. Morrison, Yu Chen, Habibul Ahsan, Patrice Watson, Henry T. Lynch, Albert De La Chapelle, Riccardo Fodde, Boris Pasche

Research output: Contribution to journalArticle

Abstract

Purpose: TGFBR1*6A is a tumor susceptibility gene that increases breast, colon, and ovarian cancer risk. Fourteen percent of the general population carries TGFBR1*6A, and TGFBR1*6A homozygotes have a greater than 100% increased colon cancer risk compared with noncarriers. Low-penetrance genes such as TGFBR1*6A may account for a sizable proportion of familial colorectal cancer occurrences. To test this hypothesis, we determined whether TGFBR1*6A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients. Patients and Methods: A case-case study was performed of 208 index patients with HNPCC meeting the Amsterdam criteria. Patients were examined for mutations and genomic rearrangements in the MLH1, MSH2, and MSH6 genes and genotyped for TGFBR1*6A. Tumor microsatellite instability status was available for 95 patients. Results: A total of 144 patients (69.2%) carried a deleterious mutation and were classified as positive for MMR gene mutation; 64 patients (30.8%) had no evidence of mutations and were classified as MMR negative. TGFBR1*6A allelic frequency was significantly higher among MMR-negative patients (0.195) than among MMR-positive patients (0.104; P = .011). The proportion of TGFBR1*6A homozygotes was nine-fold higher among MMR-negative (6.3%) than among MMR-positive patients (0.7%; P = .032). The highest TGFBR1*6A allelic frequency was found among MMR-negative patients with tumors exhibiting no microsatellite instability (0.211), and the lowest frequency was found among MMR-positive patients with tumors exhibiting microsatellite instability (0.121); the difference was not statistically significant (P = .17). Conclusion: TGFBR1*6A may be causally responsible for a proportion of HNPCC occurrences.

Original languageEnglish (US)
Pages (from-to)3074-3078
Number of pages5
JournalJournal of Clinical Oncology
Volume23
Issue number13
DOIs
StatePublished - 2005

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DNA Mismatch Repair
Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Microsatellite Instability
Mutation
Genes
Homozygote
Colonic Neoplasms
Neoplasms
Penetrance
Ovarian Neoplasms
Breast Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bian, Y., Caldes, T., Wijnen, J., Franken, P., Vasen, H., Kaklamani, V., ... Pasche, B. (2005). TGFBR1*6A may contribute to hereditary colorectal cancer. Journal of Clinical Oncology, 23(13), 3074-3078. https://doi.org/10.1200/JCO.2005.00.281

TGFBR1*6A may contribute to hereditary colorectal cancer. / Bian, Yansong; Caldes, Trinidad; Wijnen, Juul; Franken, Patrick; Vasen, Hans; Kaklamani, Virginia; Nafa, Khédoudja; Peterlongo, Paolo; Ellis, Nathan; Baron, John A.; Burn, John; Moeslein, Gabriela; Morrison, Patrick J.; Chen, Yu; Ahsan, Habibul; Watson, Patrice; Lynch, Henry T.; De La Chapelle, Albert; Fodde, Riccardo; Pasche, Boris.

In: Journal of Clinical Oncology, Vol. 23, No. 13, 2005, p. 3074-3078.

Research output: Contribution to journalArticle

Bian, Y, Caldes, T, Wijnen, J, Franken, P, Vasen, H, Kaklamani, V, Nafa, K, Peterlongo, P, Ellis, N, Baron, JA, Burn, J, Moeslein, G, Morrison, PJ, Chen, Y, Ahsan, H, Watson, P, Lynch, HT, De La Chapelle, A, Fodde, R & Pasche, B 2005, 'TGFBR1*6A may contribute to hereditary colorectal cancer', Journal of Clinical Oncology, vol. 23, no. 13, pp. 3074-3078. https://doi.org/10.1200/JCO.2005.00.281
Bian Y, Caldes T, Wijnen J, Franken P, Vasen H, Kaklamani V et al. TGFBR1*6A may contribute to hereditary colorectal cancer. Journal of Clinical Oncology. 2005;23(13):3074-3078. https://doi.org/10.1200/JCO.2005.00.281
Bian, Yansong ; Caldes, Trinidad ; Wijnen, Juul ; Franken, Patrick ; Vasen, Hans ; Kaklamani, Virginia ; Nafa, Khédoudja ; Peterlongo, Paolo ; Ellis, Nathan ; Baron, John A. ; Burn, John ; Moeslein, Gabriela ; Morrison, Patrick J. ; Chen, Yu ; Ahsan, Habibul ; Watson, Patrice ; Lynch, Henry T. ; De La Chapelle, Albert ; Fodde, Riccardo ; Pasche, Boris. / TGFBR1*6A may contribute to hereditary colorectal cancer. In: Journal of Clinical Oncology. 2005 ; Vol. 23, No. 13. pp. 3074-3078.
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title = "TGFBR1*6A may contribute to hereditary colorectal cancer",
abstract = "Purpose: TGFBR1*6A is a tumor susceptibility gene that increases breast, colon, and ovarian cancer risk. Fourteen percent of the general population carries TGFBR1*6A, and TGFBR1*6A homozygotes have a greater than 100{\%} increased colon cancer risk compared with noncarriers. Low-penetrance genes such as TGFBR1*6A may account for a sizable proportion of familial colorectal cancer occurrences. To test this hypothesis, we determined whether TGFBR1*6A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients. Patients and Methods: A case-case study was performed of 208 index patients with HNPCC meeting the Amsterdam criteria. Patients were examined for mutations and genomic rearrangements in the MLH1, MSH2, and MSH6 genes and genotyped for TGFBR1*6A. Tumor microsatellite instability status was available for 95 patients. Results: A total of 144 patients (69.2{\%}) carried a deleterious mutation and were classified as positive for MMR gene mutation; 64 patients (30.8{\%}) had no evidence of mutations and were classified as MMR negative. TGFBR1*6A allelic frequency was significantly higher among MMR-negative patients (0.195) than among MMR-positive patients (0.104; P = .011). The proportion of TGFBR1*6A homozygotes was nine-fold higher among MMR-negative (6.3{\%}) than among MMR-positive patients (0.7{\%}; P = .032). The highest TGFBR1*6A allelic frequency was found among MMR-negative patients with tumors exhibiting no microsatellite instability (0.211), and the lowest frequency was found among MMR-positive patients with tumors exhibiting microsatellite instability (0.121); the difference was not statistically significant (P = .17). Conclusion: TGFBR1*6A may be causally responsible for a proportion of HNPCC occurrences.",
author = "Yansong Bian and Trinidad Caldes and Juul Wijnen and Patrick Franken and Hans Vasen and Virginia Kaklamani and Kh{\'e}doudja Nafa and Paolo Peterlongo and Nathan Ellis and Baron, {John A.} and John Burn and Gabriela Moeslein and Morrison, {Patrick J.} and Yu Chen and Habibul Ahsan and Patrice Watson and Lynch, {Henry T.} and {De La Chapelle}, Albert and Riccardo Fodde and Boris Pasche",
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TY - JOUR

T1 - TGFBR1*6A may contribute to hereditary colorectal cancer

AU - Bian, Yansong

AU - Caldes, Trinidad

AU - Wijnen, Juul

AU - Franken, Patrick

AU - Vasen, Hans

AU - Kaklamani, Virginia

AU - Nafa, Khédoudja

AU - Peterlongo, Paolo

AU - Ellis, Nathan

AU - Baron, John A.

AU - Burn, John

AU - Moeslein, Gabriela

AU - Morrison, Patrick J.

AU - Chen, Yu

AU - Ahsan, Habibul

AU - Watson, Patrice

AU - Lynch, Henry T.

AU - De La Chapelle, Albert

AU - Fodde, Riccardo

AU - Pasche, Boris

PY - 2005

Y1 - 2005

N2 - Purpose: TGFBR1*6A is a tumor susceptibility gene that increases breast, colon, and ovarian cancer risk. Fourteen percent of the general population carries TGFBR1*6A, and TGFBR1*6A homozygotes have a greater than 100% increased colon cancer risk compared with noncarriers. Low-penetrance genes such as TGFBR1*6A may account for a sizable proportion of familial colorectal cancer occurrences. To test this hypothesis, we determined whether TGFBR1*6A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients. Patients and Methods: A case-case study was performed of 208 index patients with HNPCC meeting the Amsterdam criteria. Patients were examined for mutations and genomic rearrangements in the MLH1, MSH2, and MSH6 genes and genotyped for TGFBR1*6A. Tumor microsatellite instability status was available for 95 patients. Results: A total of 144 patients (69.2%) carried a deleterious mutation and were classified as positive for MMR gene mutation; 64 patients (30.8%) had no evidence of mutations and were classified as MMR negative. TGFBR1*6A allelic frequency was significantly higher among MMR-negative patients (0.195) than among MMR-positive patients (0.104; P = .011). The proportion of TGFBR1*6A homozygotes was nine-fold higher among MMR-negative (6.3%) than among MMR-positive patients (0.7%; P = .032). The highest TGFBR1*6A allelic frequency was found among MMR-negative patients with tumors exhibiting no microsatellite instability (0.211), and the lowest frequency was found among MMR-positive patients with tumors exhibiting microsatellite instability (0.121); the difference was not statistically significant (P = .17). Conclusion: TGFBR1*6A may be causally responsible for a proportion of HNPCC occurrences.

AB - Purpose: TGFBR1*6A is a tumor susceptibility gene that increases breast, colon, and ovarian cancer risk. Fourteen percent of the general population carries TGFBR1*6A, and TGFBR1*6A homozygotes have a greater than 100% increased colon cancer risk compared with noncarriers. Low-penetrance genes such as TGFBR1*6A may account for a sizable proportion of familial colorectal cancer occurrences. To test this hypothesis, we determined whether TGFBR1*6A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients. Patients and Methods: A case-case study was performed of 208 index patients with HNPCC meeting the Amsterdam criteria. Patients were examined for mutations and genomic rearrangements in the MLH1, MSH2, and MSH6 genes and genotyped for TGFBR1*6A. Tumor microsatellite instability status was available for 95 patients. Results: A total of 144 patients (69.2%) carried a deleterious mutation and were classified as positive for MMR gene mutation; 64 patients (30.8%) had no evidence of mutations and were classified as MMR negative. TGFBR1*6A allelic frequency was significantly higher among MMR-negative patients (0.195) than among MMR-positive patients (0.104; P = .011). The proportion of TGFBR1*6A homozygotes was nine-fold higher among MMR-negative (6.3%) than among MMR-positive patients (0.7%; P = .032). The highest TGFBR1*6A allelic frequency was found among MMR-negative patients with tumors exhibiting no microsatellite instability (0.211), and the lowest frequency was found among MMR-positive patients with tumors exhibiting microsatellite instability (0.121); the difference was not statistically significant (P = .17). Conclusion: TGFBR1*6A may be causally responsible for a proportion of HNPCC occurrences.

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