Termini and main-chain composition of monomethoxy-terminated poly(ethylene glycol) studied by two-dimensional column chromatography

Dean Lee, Iwao Teraoka

Research output: Contribution to journalArticle

Abstract

Samples of poly(ethylene glycol) especially those with functionalized ends have dimeric, trimeric, and tetrameric components at twice, three times, and four times as high a molecular weight (MW) as that of the main component. We used two-dimensional column chromatography to evaluate the MW and identify the terminal groups in each component. The first step is high osmotic pressure chromatography to prepare a sufficient amount of fractions that contain different percentages of the multimeric components. In the second step, each of the fractions was characterized by using regular size exclusion chromatography and high-resolution NMR. Decomposition of the chromatogram combined with isolation of the terminal methoxy peak in the NMR spectrum led to unique identification of the terminal groups. We thus found that the monomeric component is monomethoxy-terminated whereas the dimeric and other multimeric components are mostly dihydroxy-terminated.

Original languageEnglish (US)
Pages (from-to)2691-2697
Number of pages7
JournalPolymer
Volume43
Issue number9
StatePublished - Mar 1 2002

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Column chromatography
Polyethylene glycols
Molecular weight
Nuclear magnetic resonance
Size exclusion chromatography
Chromatography
Chemical analysis
Decomposition

Keywords

  • Chain ends
  • Poly(ethylene glycol)
  • Size exclusion chromatography

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

Cite this

Termini and main-chain composition of monomethoxy-terminated poly(ethylene glycol) studied by two-dimensional column chromatography. / Lee, Dean; Teraoka, Iwao.

In: Polymer, Vol. 43, No. 9, 01.03.2002, p. 2691-2697.

Research output: Contribution to journalArticle

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