Temporoparietal cortex in aphasia. Evidence from positron emission tomography

E. J. Metter, W. R. Hanson, C. A. Jackson, D. Kempler, D. Van Lancker, J. C. Mazziotta, M. R. Phelps

Research output: Contribution to journalArticle

Abstract

Forty-four aphasic patients were examined with (F18)-fluorodeoxyglucose positron emission tomography in a resting state to determine whether consistent glucose metabolic abnormalities were present. Ninety-seven percent of subjects showed metabolic abnormalities in the angular gyrus, 89% in the supramarginal gyrus, and 87% in the lateral and transverse superior temporal gyrus. Pearson product moment correlations were calculated between regional metabolic measures and performance on the Western Aphasia Battery. No significant correlations were found between the Western Aphasia Battery scores and right hemisphere metabolic measures. Most left hemisphere regions correlated with more than one score from the Western Aphasia Battery. Temporal but not frontal regions had significant correlations to the comprehension score. The left temporoparietal region was consistently affected in these subjects, suggesting that common features in the aphasias were caused by left temporoparietal dysfunction, while behavioral differences resulted from (1) the extent of temporoparietal changes, and (2) dsyfunction elsewhere in the brain, particularly the left frontal and subcortical areas.

Original languageEnglish (US)
Pages (from-to)1235-1238
Number of pages4
JournalArchives of Neurology
Volume47
Issue number11
StatePublished - 1990

Fingerprint

Aphasia
Positron-Emission Tomography
Parietal Lobe
Auditory Cortex
Fluorodeoxyglucose F18
Temporal Lobe
Glucose
Cortex
Positron Emission Tomography
Brain
Battery

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Metter, E. J., Hanson, W. R., Jackson, C. A., Kempler, D., Van Lancker, D., Mazziotta, J. C., & Phelps, M. R. (1990). Temporoparietal cortex in aphasia. Evidence from positron emission tomography. Archives of Neurology, 47(11), 1235-1238.

Temporoparietal cortex in aphasia. Evidence from positron emission tomography. / Metter, E. J.; Hanson, W. R.; Jackson, C. A.; Kempler, D.; Van Lancker, D.; Mazziotta, J. C.; Phelps, M. R.

In: Archives of Neurology, Vol. 47, No. 11, 1990, p. 1235-1238.

Research output: Contribution to journalArticle

Metter, EJ, Hanson, WR, Jackson, CA, Kempler, D, Van Lancker, D, Mazziotta, JC & Phelps, MR 1990, 'Temporoparietal cortex in aphasia. Evidence from positron emission tomography', Archives of Neurology, vol. 47, no. 11, pp. 1235-1238.
Metter EJ, Hanson WR, Jackson CA, Kempler D, Van Lancker D, Mazziotta JC et al. Temporoparietal cortex in aphasia. Evidence from positron emission tomography. Archives of Neurology. 1990;47(11):1235-1238.
Metter, E. J. ; Hanson, W. R. ; Jackson, C. A. ; Kempler, D. ; Van Lancker, D. ; Mazziotta, J. C. ; Phelps, M. R. / Temporoparietal cortex in aphasia. Evidence from positron emission tomography. In: Archives of Neurology. 1990 ; Vol. 47, No. 11. pp. 1235-1238.
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