Temporomandibular disorder and optimism: Relationships to ischemic pain sensitivity and interleukin-6

Nancy L. Costello, Edith E. Bragdon, Kathleen C. Light, Asgeir Sigurdsson, Shelley Bunting, Karen Grewen, William Maixner

Research output: Contribution to journalArticle

Abstract

The current study examined patients with temporomandibular disorders (TMD) (n=20) and pain-free controls (n=28) under stress and relaxation conditions. Interleukin-6 (IL-6), norepinephrine and epinephrine (NE and E) were measured both before and during each of two conditions: a non-stressful relaxation period and a speech stressor. Ischemic pain sensitivity was also assessed after each of these conditions. Optimism (Life Orientation Test (LOT)), which has been associated with better outcomes in relationship to health and disease, was also evaluated in relationship to ischemic pain tolerance and unpleasantness ratings as well as to IL-6 levels under the two conditions. Regression analysis determined the unique contribution of each predictor and the interaction between Optimism and Group (TMD versus controls) after controlling for gender and blood pressure. During stress, IL-6 levels appeared to parallel NE with only controls displaying significant increases. After controlling for depressed mood, TMD patients as a whole showed a significantly blunted response in IL-6 levels produced during stress as compared to controls (β=0.31*). Although TMD subjects as a whole did not show the expected greater pain sensitivity to the ischemic task, those displaying a less optimistic style did exhibit lower pain tolerance times (β=-0.61*) and higher pain unpleasantness ratings (β=0.48*), compared with low optimism controls and high optimism TMD patients. Less optimistic TMD patients also had higher NE and IL-6 levels during stress than other TMD patients, while optimism was unrelated to responses in controls (*P<0.05).

Original languageEnglish (US)
Pages (from-to)99-110
Number of pages12
JournalPain
Volume100
Issue number1-2
DOIs
StatePublished - Nov 1 2002

    Fingerprint

Keywords

  • Forearm ischemic pain
  • Interleukin-6
  • Norepinephrine
  • Optimism
  • Stress
  • Temporomandibular disorders

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Costello, N. L., Bragdon, E. E., Light, K. C., Sigurdsson, A., Bunting, S., Grewen, K., & Maixner, W. (2002). Temporomandibular disorder and optimism: Relationships to ischemic pain sensitivity and interleukin-6. Pain, 100(1-2), 99-110. https://doi.org/10.1016/S0304-3959(02)00263-4