Temporal structure in neuronal activity during working memory in macaque parietal cortex

Bijan Pesaran, John S. Pezaris, Maneesh Sahani, Partha P. Mitra, Richard A. Andersen

Research output: Contribution to journalArticle

Abstract

Many cortical structures have elevated firing rates during working memory, but it is not known how the activity is maintained. To investigate whether reverberating activity is important, we studied the temporal structure of local field potential (LFP) activity and spiking from area LIP in two awake macaques during a memory-saccade task. Using spectral analysis, we found spatially tuned elevated power in the gamma band (25-90 Hz) in LFP and spiking activity during the memory period. Spiking and LFP activity were also coherent in the gamma band but not at lower frequencies. Finally, we decoded LFP activity on a single-trial basis and found that LFP activity in parietal cortex discriminated between preferred and anti-preferred direction with approximately the same accuracy as the spike rate and predicted the time of a planned movement with better accuracy than the spike rate. This finding could accelerate the development of a cortical neural prosthesis.

Original languageEnglish (US)
Pages (from-to)805-811
Number of pages7
JournalNature Neuroscience
Volume5
Issue number8
DOIs
StatePublished - 2002

Fingerprint

Parietal Lobe
Macaca
Short-Term Memory
Neural Prostheses
Saccades
Power (Psychology)
Direction compound

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Temporal structure in neuronal activity during working memory in macaque parietal cortex. / Pesaran, Bijan; Pezaris, John S.; Sahani, Maneesh; Mitra, Partha P.; Andersen, Richard A.

In: Nature Neuroscience, Vol. 5, No. 8, 2002, p. 805-811.

Research output: Contribution to journalArticle

Pesaran, Bijan ; Pezaris, John S. ; Sahani, Maneesh ; Mitra, Partha P. ; Andersen, Richard A. / Temporal structure in neuronal activity during working memory in macaque parietal cortex. In: Nature Neuroscience. 2002 ; Vol. 5, No. 8. pp. 805-811.
@article{e8e157af96674a779bbff44dd1cc9748,
title = "Temporal structure in neuronal activity during working memory in macaque parietal cortex",
abstract = "Many cortical structures have elevated firing rates during working memory, but it is not known how the activity is maintained. To investigate whether reverberating activity is important, we studied the temporal structure of local field potential (LFP) activity and spiking from area LIP in two awake macaques during a memory-saccade task. Using spectral analysis, we found spatially tuned elevated power in the gamma band (25-90 Hz) in LFP and spiking activity during the memory period. Spiking and LFP activity were also coherent in the gamma band but not at lower frequencies. Finally, we decoded LFP activity on a single-trial basis and found that LFP activity in parietal cortex discriminated between preferred and anti-preferred direction with approximately the same accuracy as the spike rate and predicted the time of a planned movement with better accuracy than the spike rate. This finding could accelerate the development of a cortical neural prosthesis.",
author = "Bijan Pesaran and Pezaris, {John S.} and Maneesh Sahani and Mitra, {Partha P.} and Andersen, {Richard A.}",
year = "2002",
doi = "10.1038/nn890",
language = "English (US)",
volume = "5",
pages = "805--811",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Temporal structure in neuronal activity during working memory in macaque parietal cortex

AU - Pesaran, Bijan

AU - Pezaris, John S.

AU - Sahani, Maneesh

AU - Mitra, Partha P.

AU - Andersen, Richard A.

PY - 2002

Y1 - 2002

N2 - Many cortical structures have elevated firing rates during working memory, but it is not known how the activity is maintained. To investigate whether reverberating activity is important, we studied the temporal structure of local field potential (LFP) activity and spiking from area LIP in two awake macaques during a memory-saccade task. Using spectral analysis, we found spatially tuned elevated power in the gamma band (25-90 Hz) in LFP and spiking activity during the memory period. Spiking and LFP activity were also coherent in the gamma band but not at lower frequencies. Finally, we decoded LFP activity on a single-trial basis and found that LFP activity in parietal cortex discriminated between preferred and anti-preferred direction with approximately the same accuracy as the spike rate and predicted the time of a planned movement with better accuracy than the spike rate. This finding could accelerate the development of a cortical neural prosthesis.

AB - Many cortical structures have elevated firing rates during working memory, but it is not known how the activity is maintained. To investigate whether reverberating activity is important, we studied the temporal structure of local field potential (LFP) activity and spiking from area LIP in two awake macaques during a memory-saccade task. Using spectral analysis, we found spatially tuned elevated power in the gamma band (25-90 Hz) in LFP and spiking activity during the memory period. Spiking and LFP activity were also coherent in the gamma band but not at lower frequencies. Finally, we decoded LFP activity on a single-trial basis and found that LFP activity in parietal cortex discriminated between preferred and anti-preferred direction with approximately the same accuracy as the spike rate and predicted the time of a planned movement with better accuracy than the spike rate. This finding could accelerate the development of a cortical neural prosthesis.

UR - http://www.scopus.com/inward/record.url?scp=0036321059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036321059&partnerID=8YFLogxK

U2 - 10.1038/nn890

DO - 10.1038/nn890

M3 - Article

VL - 5

SP - 805

EP - 811

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 8

ER -