Temporal Phases of Activity-Dependent Plasticity and Memory Are Mediated by Compartmentalized Routing of MAPK Signaling in Aplysia Sensory Neurons

Justin L. Shobe, Yali Zhao, Shara Stough, Xiaojing Ye, Vickie Hsuan, Kelsey C. Martin, Thomas Carew

Research output: Contribution to journalArticle

Abstract

An activity-dependent form of intermediate memory (AD-ITM) for sensitization is induced in Aplysia by a single tail shock that gives rise to plastic changes (AD-ITF) in tail sensory neurons (SNs) via the interaction of action potential firing in the SN coupled with the release of serotonin in the CNS. Activity-dependent long-term facilitation (AD-LTF, lasting >24hr) requires protein synthesis dependent persistent mitogen-activated protein kinase (MAPK) activation and translocation to the SN nucleus. We now show that the induction of the earlier temporal phase (AD-ITM and AD-ITF), which is translation and transcription independent, requires the activation of a compartmentally distinct novel signaling cascade that links second messengers, MAPK and PKC into a unified pathway within tail SNs. Since both AD-ITM and AD-LTM require MAPK activity, these collective findings suggest that presynaptic SNs route the flow of molecular information to distinct subcellular compartments during the induction of activity-dependent long-lasting memories.

Original languageEnglish (US)
Pages (from-to)113-125
Number of pages13
JournalNeuron
Volume61
Issue number1
DOIs
StatePublished - Jan 15 2009

Fingerprint

Aplysia
Sensory Receptor Cells
Mitogen-Activated Protein Kinases
Tail
Second Messenger Systems
Protein Transport
Action Potentials
Shock
Serotonin
Proteins

Keywords

  • CELLBIO
  • MOLNEURO
  • SIGNALING

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Temporal Phases of Activity-Dependent Plasticity and Memory Are Mediated by Compartmentalized Routing of MAPK Signaling in Aplysia Sensory Neurons. / Shobe, Justin L.; Zhao, Yali; Stough, Shara; Ye, Xiaojing; Hsuan, Vickie; Martin, Kelsey C.; Carew, Thomas.

In: Neuron, Vol. 61, No. 1, 15.01.2009, p. 113-125.

Research output: Contribution to journalArticle

Shobe, Justin L. ; Zhao, Yali ; Stough, Shara ; Ye, Xiaojing ; Hsuan, Vickie ; Martin, Kelsey C. ; Carew, Thomas. / Temporal Phases of Activity-Dependent Plasticity and Memory Are Mediated by Compartmentalized Routing of MAPK Signaling in Aplysia Sensory Neurons. In: Neuron. 2009 ; Vol. 61, No. 1. pp. 113-125.
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