Temporal patterning of neuroblasts controls notch-mediated cell survival through regulation of hid or reaper

Claire Bertet, Xin Li, Ted Erclik, Matthieu Cavey, Brent Wells, Claude Desplan

Research output: Contribution to journalArticle

Abstract

Temporal patterning of neural progenitors is one of the core mechanisms generating neuronal diversity in the central nervous system. Here, we show that, in the tips of the outer proliferation center (tOPC) of the developing Drosophila optic lobes, a unique temporal series of transcription factors not only governs the sequential production of distinct neuronal subtypes but also controls the mode of progenitor division, as well as the selective apoptosis of NotchOFF or NotchON neurons during binary cell fate decisions. Within a single lineage, intermediate precursors initially do not divide and generate only one neuron; subsequently, precursors divide, but their NotchON progeny systematically die through Reaper activity, whereas later, their NotchOFF progeny die through Hid activity. These mechanisms dictate how the tOPC produces neurons for three different optic ganglia. We conclude that temporal patterning generates neuronal diversity by specifying both the identity and survival/death of each unique neuronal subtype.

Original languageEnglish (US)
Pages (from-to)1173-1186
Number of pages14
JournalCell
Volume158
Issue number5
DOIs
StatePublished - Aug 28 2014

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Neurons
Cell Survival
Cells
Optics
Neurology
Ganglia
Drosophila
Transcription Factors
Central Nervous System
Apoptosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Temporal patterning of neuroblasts controls notch-mediated cell survival through regulation of hid or reaper. / Bertet, Claire; Li, Xin; Erclik, Ted; Cavey, Matthieu; Wells, Brent; Desplan, Claude.

In: Cell, Vol. 158, No. 5, 28.08.2014, p. 1173-1186.

Research output: Contribution to journalArticle

Bertet, Claire ; Li, Xin ; Erclik, Ted ; Cavey, Matthieu ; Wells, Brent ; Desplan, Claude. / Temporal patterning of neuroblasts controls notch-mediated cell survival through regulation of hid or reaper. In: Cell. 2014 ; Vol. 158, No. 5. pp. 1173-1186.
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