Temporal memory is shaped by encoding stability and intervening item reactivation

Sarah DuBrow, Lila Davachi

Research output: Contribution to journalArticle

Abstract

Making sense of previous experience requires remembering the order in which events unfolded in time. Prior work has implicated the hippocampus and medial temporal lobe cortex in memory for temporal information associated with individual episodes. However, the processes involved in encoding and retrieving temporal information across extended sequences isrelatively poorly understood. Here we used fMRI during the encoding and retrieval of extended sequences to test specific predictions about the type of information used to resolve temporal order and the role of the hippocampus in this process. Participants studied sequences of images of celebrity faces and common objects followed by a recency discrimination test. The main conditions of interest were pairs of items that had been presented with three intervening items, half of which included an intervening category shift. During encoding, hippocampal pattern similarity across intervening items was associated with subsequent successful ordermemory. To test for evidence of associative retrieval, wetrained a classifier to discriminate encoding patterns associated with faces versus objects and applied the classifier on fMRI patterns during recency discrimination. We found evidence that the category content of intervening items was reactivated during recency judgments, and this was related to hippocampal encoding-retrieval similarity. A follow-up behavioral priming experiment revealed additional evidence for intervening item reinstatement during temporal order judgments. Reinstatement did not differ according to whether the items occurred withinasingle contextoracross context boundaries. Thus, these data suggest that inter-item associative encoding and retrieval mediated by the hippocampus contribute to temporal order memory.

Original languageEnglish (US)
Pages (from-to)13998-14005
Number of pages8
JournalJournal of Neuroscience
Volume34
Issue number42
DOIs
StatePublished - Oct 15 2014

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Hippocampus
Temporal Lobe
Magnetic Resonance Imaging
Discrimination (Psychology)

Keywords

  • Event segmentation
  • fMRI
  • Hippocampus
  • MVPA
  • Temporal order

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Temporal memory is shaped by encoding stability and intervening item reactivation. / DuBrow, Sarah; Davachi, Lila.

In: Journal of Neuroscience, Vol. 34, No. 42, 15.10.2014, p. 13998-14005.

Research output: Contribution to journalArticle

DuBrow, Sarah ; Davachi, Lila. / Temporal memory is shaped by encoding stability and intervening item reactivation. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 42. pp. 13998-14005.
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