Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus

Kathryn A. Lee, Caryl Gay, Janice Humphreys, Carmen J. Portillo, Clive R. Pullinger, Bradley E. Aouizerat

Research output: Contribution to journalArticle

Abstract

Background and Study Objective: Telomere length provides an estimate of cellular aging and is influenced by oxidative stress and health behaviors such as diet and exercise. This article describes relationships between telomere length and sleep parameters that included total sleep time (TST), wake after sleep onset (WASO), and self-reported sleep quality in a sample of adults with chronic illness. Design and Participants: Cross-sectional study of 283 adults (74% male, 42% Caucasian) infected with human immunodeficiency virus (HIV) while living in the San Francisco Bay area, CA, USA. Ages ranged from 22-77 y. Measurements and Results: TST and WASO were estimated with wrist actigraphy across 72 h; self-reported sleep quality was assessed with the Pittsburgh Sleep Quality Index. Relative telomere length (RTL) in leukocytes was estimated by quantitative polymerase chain reaction assays. Shorter RTL was associated with older age, and RTL was shorter in males than females. RTL was unrelated to HIV disease characteristics. RTL was not associated with WASO or self-reported sleep quality. Participants with at least 7 h sleep had longer RTL than those with less than 7 h, even after controlling for the effects of age, sex, race, education, body mass index, metabolic hormones (i.e., leptin, ghrelin, adiponectin, and resistin), depression and anxiety, and sleep quality. Conclusion: Results suggest that sleep duration is associated with preserving telomere length in a population of human immunodeficiency virusinfected adults. Getting at least 7 hours of sleep at night may either protect telomeres from damage or restore them on a nightly basis.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalSleep
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Telomere
Sleep
HIV
Actigraphy
Resistin
Ghrelin
Sex Education
San Francisco
Cell Aging
Adiponectin
Health Behavior
Virus Diseases
Leptin
Wrist
Oxidative Stress
Body Mass Index
Leukocytes
Chronic Disease
Anxiety

Keywords

  • Actigraphy
  • Body mass index
  • HIV
  • Metabolic hormones
  • Telomere

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus. / Lee, Kathryn A.; Gay, Caryl; Humphreys, Janice; Portillo, Carmen J.; Pullinger, Clive R.; Aouizerat, Bradley E.

In: Sleep, Vol. 37, No. 1, 01.01.2014, p. 157-166.

Research output: Contribution to journalArticle

Lee, Kathryn A. ; Gay, Caryl ; Humphreys, Janice ; Portillo, Carmen J. ; Pullinger, Clive R. ; Aouizerat, Bradley E. / Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus. In: Sleep. 2014 ; Vol. 37, No. 1. pp. 157-166.
@article{68663ff18ecc4c49962e8c2352d05108,
title = "Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus",
abstract = "Background and Study Objective: Telomere length provides an estimate of cellular aging and is influenced by oxidative stress and health behaviors such as diet and exercise. This article describes relationships between telomere length and sleep parameters that included total sleep time (TST), wake after sleep onset (WASO), and self-reported sleep quality in a sample of adults with chronic illness. Design and Participants: Cross-sectional study of 283 adults (74{\%} male, 42{\%} Caucasian) infected with human immunodeficiency virus (HIV) while living in the San Francisco Bay area, CA, USA. Ages ranged from 22-77 y. Measurements and Results: TST and WASO were estimated with wrist actigraphy across 72 h; self-reported sleep quality was assessed with the Pittsburgh Sleep Quality Index. Relative telomere length (RTL) in leukocytes was estimated by quantitative polymerase chain reaction assays. Shorter RTL was associated with older age, and RTL was shorter in males than females. RTL was unrelated to HIV disease characteristics. RTL was not associated with WASO or self-reported sleep quality. Participants with at least 7 h sleep had longer RTL than those with less than 7 h, even after controlling for the effects of age, sex, race, education, body mass index, metabolic hormones (i.e., leptin, ghrelin, adiponectin, and resistin), depression and anxiety, and sleep quality. Conclusion: Results suggest that sleep duration is associated with preserving telomere length in a population of human immunodeficiency virusinfected adults. Getting at least 7 hours of sleep at night may either protect telomeres from damage or restore them on a nightly basis.",
keywords = "Actigraphy, Body mass index, HIV, Metabolic hormones, Telomere",
author = "Lee, {Kathryn A.} and Caryl Gay and Janice Humphreys and Portillo, {Carmen J.} and Pullinger, {Clive R.} and Aouizerat, {Bradley E.}",
year = "2014",
month = "1",
day = "1",
doi = "10.5665/sleep.3328",
language = "English (US)",
volume = "37",
pages = "157--166",
journal = "Sleep",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "1",

}

TY - JOUR

T1 - Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus

AU - Lee, Kathryn A.

AU - Gay, Caryl

AU - Humphreys, Janice

AU - Portillo, Carmen J.

AU - Pullinger, Clive R.

AU - Aouizerat, Bradley E.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background and Study Objective: Telomere length provides an estimate of cellular aging and is influenced by oxidative stress and health behaviors such as diet and exercise. This article describes relationships between telomere length and sleep parameters that included total sleep time (TST), wake after sleep onset (WASO), and self-reported sleep quality in a sample of adults with chronic illness. Design and Participants: Cross-sectional study of 283 adults (74% male, 42% Caucasian) infected with human immunodeficiency virus (HIV) while living in the San Francisco Bay area, CA, USA. Ages ranged from 22-77 y. Measurements and Results: TST and WASO were estimated with wrist actigraphy across 72 h; self-reported sleep quality was assessed with the Pittsburgh Sleep Quality Index. Relative telomere length (RTL) in leukocytes was estimated by quantitative polymerase chain reaction assays. Shorter RTL was associated with older age, and RTL was shorter in males than females. RTL was unrelated to HIV disease characteristics. RTL was not associated with WASO or self-reported sleep quality. Participants with at least 7 h sleep had longer RTL than those with less than 7 h, even after controlling for the effects of age, sex, race, education, body mass index, metabolic hormones (i.e., leptin, ghrelin, adiponectin, and resistin), depression and anxiety, and sleep quality. Conclusion: Results suggest that sleep duration is associated with preserving telomere length in a population of human immunodeficiency virusinfected adults. Getting at least 7 hours of sleep at night may either protect telomeres from damage or restore them on a nightly basis.

AB - Background and Study Objective: Telomere length provides an estimate of cellular aging and is influenced by oxidative stress and health behaviors such as diet and exercise. This article describes relationships between telomere length and sleep parameters that included total sleep time (TST), wake after sleep onset (WASO), and self-reported sleep quality in a sample of adults with chronic illness. Design and Participants: Cross-sectional study of 283 adults (74% male, 42% Caucasian) infected with human immunodeficiency virus (HIV) while living in the San Francisco Bay area, CA, USA. Ages ranged from 22-77 y. Measurements and Results: TST and WASO were estimated with wrist actigraphy across 72 h; self-reported sleep quality was assessed with the Pittsburgh Sleep Quality Index. Relative telomere length (RTL) in leukocytes was estimated by quantitative polymerase chain reaction assays. Shorter RTL was associated with older age, and RTL was shorter in males than females. RTL was unrelated to HIV disease characteristics. RTL was not associated with WASO or self-reported sleep quality. Participants with at least 7 h sleep had longer RTL than those with less than 7 h, even after controlling for the effects of age, sex, race, education, body mass index, metabolic hormones (i.e., leptin, ghrelin, adiponectin, and resistin), depression and anxiety, and sleep quality. Conclusion: Results suggest that sleep duration is associated with preserving telomere length in a population of human immunodeficiency virusinfected adults. Getting at least 7 hours of sleep at night may either protect telomeres from damage or restore them on a nightly basis.

KW - Actigraphy

KW - Body mass index

KW - HIV

KW - Metabolic hormones

KW - Telomere

UR - http://www.scopus.com/inward/record.url?scp=84891781212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891781212&partnerID=8YFLogxK

U2 - 10.5665/sleep.3328

DO - 10.5665/sleep.3328

M3 - Article

VL - 37

SP - 157

EP - 166

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 1

ER -