Telencephalic progenitors maintain anteroposterior identities cell autonomously

Erqian Na, Maria McCarthy, Christine Neyt, Eseng Lai, Gordon Fishell

    Research output: Contribution to journalArticle

    Abstract

    Grafting experiments have demonstrated that determination of anteroposterior (AP) identity is an early step in neural patterning that precedes dorsoventral (DV) specification. These studies used pieces of tissue, however, rather than individual cells to address this question. It thus remains unclear whether the maintenance of AP identity is a cell-autonomous property or a result of signaling between cells within the grafted tissue. Previously, we and others have used transplants of dissociated brain cells to show that individual telencephalic precursor cells can adopt host-specific DV identities when they integrate within novel regions of the telencephalon. We have now undertaken a set of transplantations during the same mid-neurogenic period used in the previous studies to assess the ability of telencephalic progenitors to integrate and differentiate into more posterior regions of the neuraxis. We observed that telencephalic progenitors were capable of integrating and migrating within different AP levels of the central nervous system (CNS). Despite this, we found that telencephalic progenitors that integrated within the diencephalon and the mesencephalon continued to express a telencephalic marker until adulthood. We speculate that during neurogenesis individual progenitors are determined in terms of their AP but not their DV identity. Hence, AP identity is maintained cell autonomously within individual progenitors.

    Original languageEnglish (US)
    Pages (from-to)987-990
    Number of pages4
    JournalCurrent Biology
    Volume8
    Issue number17
    StatePublished - Aug 27 1998

    Fingerprint

    Telencephalon
    Tissue
    Cell signaling
    Transplants
    Neurology
    Brain
    cells
    Specifications
    Diencephalon
    neurogenesis
    Experiments
    Neurogenesis
    Mesencephalon
    adulthood
    central nervous system
    Central Nervous System
    Transplantation
    Maintenance
    brain

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)

    Cite this

    Na, E., McCarthy, M., Neyt, C., Lai, E., & Fishell, G. (1998). Telencephalic progenitors maintain anteroposterior identities cell autonomously. Current Biology, 8(17), 987-990.

    Telencephalic progenitors maintain anteroposterior identities cell autonomously. / Na, Erqian; McCarthy, Maria; Neyt, Christine; Lai, Eseng; Fishell, Gordon.

    In: Current Biology, Vol. 8, No. 17, 27.08.1998, p. 987-990.

    Research output: Contribution to journalArticle

    Na, E, McCarthy, M, Neyt, C, Lai, E & Fishell, G 1998, 'Telencephalic progenitors maintain anteroposterior identities cell autonomously', Current Biology, vol. 8, no. 17, pp. 987-990.
    Na E, McCarthy M, Neyt C, Lai E, Fishell G. Telencephalic progenitors maintain anteroposterior identities cell autonomously. Current Biology. 1998 Aug 27;8(17):987-990.
    Na, Erqian ; McCarthy, Maria ; Neyt, Christine ; Lai, Eseng ; Fishell, Gordon. / Telencephalic progenitors maintain anteroposterior identities cell autonomously. In: Current Biology. 1998 ; Vol. 8, No. 17. pp. 987-990.
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