Telencephalic progenitors maintain anteroposterior identities cell autonomously

Erqian Na, Maria McCarthy, Christine Neyt, Eseng Lai, Gordon Fishell

Research output: Contribution to journalArticle

Abstract

Grafting experiments have demonstrated that determination of anteroposterior (AP) identity is an early step in neural patterning that precedes dorsoventral (DV) specification. These studies used pieces of tissue, however, rather than individual cells to address this question. It thus remains unclear whether the maintenance of AP identity is a cell-autonomous property or a result of signaling between cells within the grafted tissue. Previously, we and others have used transplants of dissociated brain cells to show that individual telencephalic precursor cells can adopt host-specific DV identities when they integrate within novel regions of the telencephalon. We have now undertaken a set of transplantations during the same mid-neurogenic period used in the previous studies to assess the ability of telencephalic progenitors to integrate and differentiate into more posterior regions of the neuraxis. We observed that telencephalic progenitors were capable of integrating and migrating within different AP levels of the central nervous system (CNS). Despite this, we found that telencephalic progenitors that integrated within the diencephalon and the mesencephalon continued to express a telencephalic marker until adulthood. We speculate that during neurogenesis individual progenitors are determined in terms of their AP but not their DV identity. Hence, AP identity is maintained cell autonomously within individual progenitors.

Original languageEnglish (US)
Pages (from-to)987-990
Number of pages4
JournalCurrent Biology
Volume8
Issue number17
StatePublished - Aug 27 1998

Fingerprint

Telencephalon
Tissue
Cell signaling
Transplants
Neurology
Brain
cells
Specifications
Diencephalon
neurogenesis
Experiments
Neurogenesis
Mesencephalon
adulthood
central nervous system
Central Nervous System
Transplantation
Maintenance
brain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Telencephalic progenitors maintain anteroposterior identities cell autonomously. / Na, Erqian; McCarthy, Maria; Neyt, Christine; Lai, Eseng; Fishell, Gordon.

In: Current Biology, Vol. 8, No. 17, 27.08.1998, p. 987-990.

Research output: Contribution to journalArticle

Na, E, McCarthy, M, Neyt, C, Lai, E & Fishell, G 1998, 'Telencephalic progenitors maintain anteroposterior identities cell autonomously', Current Biology, vol. 8, no. 17, pp. 987-990.
Na, Erqian ; McCarthy, Maria ; Neyt, Christine ; Lai, Eseng ; Fishell, Gordon. / Telencephalic progenitors maintain anteroposterior identities cell autonomously. In: Current Biology. 1998 ; Vol. 8, No. 17. pp. 987-990.
@article{a5026241d0714f21b34d8c664555b437,
title = "Telencephalic progenitors maintain anteroposterior identities cell autonomously",
abstract = "Grafting experiments have demonstrated that determination of anteroposterior (AP) identity is an early step in neural patterning that precedes dorsoventral (DV) specification. These studies used pieces of tissue, however, rather than individual cells to address this question. It thus remains unclear whether the maintenance of AP identity is a cell-autonomous property or a result of signaling between cells within the grafted tissue. Previously, we and others have used transplants of dissociated brain cells to show that individual telencephalic precursor cells can adopt host-specific DV identities when they integrate within novel regions of the telencephalon. We have now undertaken a set of transplantations during the same mid-neurogenic period used in the previous studies to assess the ability of telencephalic progenitors to integrate and differentiate into more posterior regions of the neuraxis. We observed that telencephalic progenitors were capable of integrating and migrating within different AP levels of the central nervous system (CNS). Despite this, we found that telencephalic progenitors that integrated within the diencephalon and the mesencephalon continued to express a telencephalic marker until adulthood. We speculate that during neurogenesis individual progenitors are determined in terms of their AP but not their DV identity. Hence, AP identity is maintained cell autonomously within individual progenitors.",
author = "Erqian Na and Maria McCarthy and Christine Neyt and Eseng Lai and Gordon Fishell",
year = "1998",
month = "8",
day = "27",
language = "English (US)",
volume = "8",
pages = "987--990",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "17",

}

TY - JOUR

T1 - Telencephalic progenitors maintain anteroposterior identities cell autonomously

AU - Na, Erqian

AU - McCarthy, Maria

AU - Neyt, Christine

AU - Lai, Eseng

AU - Fishell, Gordon

PY - 1998/8/27

Y1 - 1998/8/27

N2 - Grafting experiments have demonstrated that determination of anteroposterior (AP) identity is an early step in neural patterning that precedes dorsoventral (DV) specification. These studies used pieces of tissue, however, rather than individual cells to address this question. It thus remains unclear whether the maintenance of AP identity is a cell-autonomous property or a result of signaling between cells within the grafted tissue. Previously, we and others have used transplants of dissociated brain cells to show that individual telencephalic precursor cells can adopt host-specific DV identities when they integrate within novel regions of the telencephalon. We have now undertaken a set of transplantations during the same mid-neurogenic period used in the previous studies to assess the ability of telencephalic progenitors to integrate and differentiate into more posterior regions of the neuraxis. We observed that telencephalic progenitors were capable of integrating and migrating within different AP levels of the central nervous system (CNS). Despite this, we found that telencephalic progenitors that integrated within the diencephalon and the mesencephalon continued to express a telencephalic marker until adulthood. We speculate that during neurogenesis individual progenitors are determined in terms of their AP but not their DV identity. Hence, AP identity is maintained cell autonomously within individual progenitors.

AB - Grafting experiments have demonstrated that determination of anteroposterior (AP) identity is an early step in neural patterning that precedes dorsoventral (DV) specification. These studies used pieces of tissue, however, rather than individual cells to address this question. It thus remains unclear whether the maintenance of AP identity is a cell-autonomous property or a result of signaling between cells within the grafted tissue. Previously, we and others have used transplants of dissociated brain cells to show that individual telencephalic precursor cells can adopt host-specific DV identities when they integrate within novel regions of the telencephalon. We have now undertaken a set of transplantations during the same mid-neurogenic period used in the previous studies to assess the ability of telencephalic progenitors to integrate and differentiate into more posterior regions of the neuraxis. We observed that telencephalic progenitors were capable of integrating and migrating within different AP levels of the central nervous system (CNS). Despite this, we found that telencephalic progenitors that integrated within the diencephalon and the mesencephalon continued to express a telencephalic marker until adulthood. We speculate that during neurogenesis individual progenitors are determined in terms of their AP but not their DV identity. Hence, AP identity is maintained cell autonomously within individual progenitors.

UR - http://www.scopus.com/inward/record.url?scp=0032572693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032572693&partnerID=8YFLogxK

M3 - Article

C2 - 9742404

AN - SCOPUS:0032572693

VL - 8

SP - 987

EP - 990

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 17

ER -