Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses

Nikita Rudinskiy, Jonathan M. Hawkes, Susanne Wegmann, Kishore V. Kuchibhotla, Alona Muzikansky, Rebecca Betensky, Tara L. Spires-Jones, Bradley T. Hyman

Research output: Contribution to journalArticle

Abstract

Intraneuronal neurofibrillary tangles (NFTs) - a characteristic pathological feature of Alzheimer's and several other neurodegenerative diseases - are considered a major target for drug development. Tangle load correlates well with the severity of cognitive symptoms and mouse models of tauopathy are behaviorally impaired. However, there is little evidence that NFTs directly impact physiological properties of host neurons. Here we used a transgenic mouse model of tauopathy to study how advanced tau pathology in different brain regions affects activity-driven expression of immediate-early gene Arc required for experience-dependent consolidation of long-term memories. We demonstrate in vivo that visual cortex neurons with tangles are as likely to express comparable amounts of Arc in response to structured visual stimulation as their neighbors without tangles. Probability of experience-dependent Arc response was not affected by tau tangles in both visual cortex and hippocampal pyramidal neurons as determined postmortem. Moreover, whole brain analysis showed that network-wide activity-driven Arc expression was not affected by tau pathology in any of the brain regions, including brain areas with the highest tangle load. Our findings suggest that intraneuronal NFTs do not affect signaling cascades leading to experience-dependent gene expression required for long-term synaptic plasticity.

Original languageEnglish (US)
Article number63
JournalActa neuropathologica communications
Volume2
Issue number1
DOIs
StatePublished - Jan 27 2014

Fingerprint

Neurofibrillary Tangles
Tauopathies
Pathology
Neurons
Brain
Visual Cortex
Photic Stimulation
Neurobehavioral Manifestations
Neuronal Plasticity
Immediate-Early Genes
Long-Term Memory
Pyramidal Cells
Neurodegenerative Diseases
Transgenic Mice
Gene Expression
Pharmaceutical Preparations

Keywords

  • Activity-dependent expression
  • Alzheimer's disease
  • Arc
  • Neurofibrillary tangles
  • Neuronal activity
  • Tau

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses. / Rudinskiy, Nikita; Hawkes, Jonathan M.; Wegmann, Susanne; Kuchibhotla, Kishore V.; Muzikansky, Alona; Betensky, Rebecca; Spires-Jones, Tara L.; Hyman, Bradley T.

In: Acta neuropathologica communications, Vol. 2, No. 1, 63, 27.01.2014.

Research output: Contribution to journalArticle

Rudinskiy, N, Hawkes, JM, Wegmann, S, Kuchibhotla, KV, Muzikansky, A, Betensky, R, Spires-Jones, TL & Hyman, BT 2014, 'Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses', Acta neuropathologica communications, vol. 2, no. 1, 63. https://doi.org/10.1186/2051-5960-2-63
Rudinskiy, Nikita ; Hawkes, Jonathan M. ; Wegmann, Susanne ; Kuchibhotla, Kishore V. ; Muzikansky, Alona ; Betensky, Rebecca ; Spires-Jones, Tara L. ; Hyman, Bradley T. / Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses. In: Acta neuropathologica communications. 2014 ; Vol. 2, No. 1.
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