Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

Daniel A. Lee, Joseph L. Bedont, Thomas Pak, Hong Wang, Juan Song, Ana Miranda-Angulo, Vani Takiar, Vanessa Charubhumi, Francesca Balordi, Hirohide Takebayashi, Susan Aja, Eric Ford, Gordon Fishell, Seth Blackshaw

    Research output: Contribution to journalArticle

    Abstract

    Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.

    Original languageEnglish (US)
    Pages (from-to)700-702
    Number of pages3
    JournalNature Neuroscience
    Volume15
    Issue number5
    DOIs
    StatePublished - May 1 2012

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    Ependymoglial Cells
    Median Eminence
    Neurogenesis
    Diet
    Neurons
    Hypothalamus
    Weights and Measures

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., ... Blackshaw, S. (2012). Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nature Neuroscience, 15(5), 700-702. https://doi.org/10.1038/nn.3079

    Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. / Lee, Daniel A.; Bedont, Joseph L.; Pak, Thomas; Wang, Hong; Song, Juan; Miranda-Angulo, Ana; Takiar, Vani; Charubhumi, Vanessa; Balordi, Francesca; Takebayashi, Hirohide; Aja, Susan; Ford, Eric; Fishell, Gordon; Blackshaw, Seth.

    In: Nature Neuroscience, Vol. 15, No. 5, 01.05.2012, p. 700-702.

    Research output: Contribution to journalArticle

    Lee, DA, Bedont, JL, Pak, T, Wang, H, Song, J, Miranda-Angulo, A, Takiar, V, Charubhumi, V, Balordi, F, Takebayashi, H, Aja, S, Ford, E, Fishell, G & Blackshaw, S 2012, 'Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche', Nature Neuroscience, vol. 15, no. 5, pp. 700-702. https://doi.org/10.1038/nn.3079
    Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A et al. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nature Neuroscience. 2012 May 1;15(5):700-702. https://doi.org/10.1038/nn.3079
    Lee, Daniel A. ; Bedont, Joseph L. ; Pak, Thomas ; Wang, Hong ; Song, Juan ; Miranda-Angulo, Ana ; Takiar, Vani ; Charubhumi, Vanessa ; Balordi, Francesca ; Takebayashi, Hirohide ; Aja, Susan ; Ford, Eric ; Fishell, Gordon ; Blackshaw, Seth. / Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. In: Nature Neuroscience. 2012 ; Vol. 15, No. 5. pp. 700-702.
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