Taking whispering gallery-mode single virus detection and sizing to the limit

V. R. Dantham, S. Holler, V. Kolchenko, Z. Wan, S. Arnold

Research output: Contribution to journalArticle

Abstract

We report the label-free detection and sizing by a microcavity of the smallest individual RNA virus, MS2, with a mass only ∼1 of InfluenzaA (6 vs. 512 ag). Although detection of such a small bio-nano-particle has been beyond the reach of a bare spherical microcavity, it was accomplished with ease (S/N 8, Q 4 × 10 5) using a single dipole stimulated plasmonic-nanoshell as a microcavity wavelength shift enhancer, providing an enhancement of ∼70×, in agreement with theory. Unique wavelength shift statistics are recorded consistent with an ultra-uniform genetically programmed substance that is drawn to the plasmonic hot spots by light-forces.

Original languageEnglish (US)
Article number043704
JournalApplied Physics Letters
Volume101
Issue number4
DOIs
StatePublished - Jul 23 2012

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whispering gallery modes
sizing
viruses
shift
wavelengths
statistics
dipoles
augmentation

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Taking whispering gallery-mode single virus detection and sizing to the limit. / Dantham, V. R.; Holler, S.; Kolchenko, V.; Wan, Z.; Arnold, S.

In: Applied Physics Letters, Vol. 101, No. 4, 043704, 23.07.2012.

Research output: Contribution to journalArticle

Dantham, V. R. ; Holler, S. ; Kolchenko, V. ; Wan, Z. ; Arnold, S. / Taking whispering gallery-mode single virus detection and sizing to the limit. In: Applied Physics Letters. 2012 ; Vol. 101, No. 4.
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