Tailoring tripodal ligands for zinc sensing

Zhaohua Dai, James Canary

Research output: Contribution to journalArticle

Abstract

Zinc plays an important role in biological processes. It is implicated in many diseases, including those affecting the brain. Imaging zinc is becoming crucial to the elucidation of zinc concentration, distribution, kinetics and functions in cells and tissues. This review highlights recent advances in the development of picolylamine-based tripodal compounds as zinc sensors, especially our work in the field of sensing "invisible" Zn(II) using steady-state fluorescence, fluorescence lifetimes and chiroptical spectroscopy. Our approach has emphasized creative ligand design and detection schemes. Utilizing tris(2-pyridylmethyl)amine-based N4 tripodal ligands has provided a flexible system for engineering zinc sensors with improved sensitivity, selectivity and contrast. Also included are results with tripodal ligands that have focused more on applications.

Original languageEnglish (US)
Pages (from-to)1708-1718
Number of pages11
JournalNew Journal of Chemistry
Volume31
Issue number10
DOIs
StatePublished - 2007

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Zinc
Ligands
Fluorescence
Sensors
Amines
Brain
Spectroscopy
Tissue
Imaging techniques
Kinetics

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Tailoring tripodal ligands for zinc sensing. / Dai, Zhaohua; Canary, James.

In: New Journal of Chemistry, Vol. 31, No. 10, 2007, p. 1708-1718.

Research output: Contribution to journalArticle

Dai, Zhaohua ; Canary, James. / Tailoring tripodal ligands for zinc sensing. In: New Journal of Chemistry. 2007 ; Vol. 31, No. 10. pp. 1708-1718.
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