Tailoring of high-order multiple emulsions by the liquid-liquid phase separation of ternary mixtures

Martin F. Haase, Jasna Brujic

    Research output: Contribution to journalArticle

    Abstract

    Multiple emulsions with an "onion" topology are useful vehicles for drug delivery, biochemical assays, and templating materials. They can be assembled by ternary liquid phase separation by microfluidics, but the control over their design is limited because the mechanism for their creation is unknown. Herein we show that phase separation occurs through self-similar cycles of mass transfer, spinodal decomposition or nucleation, and coalescence into multiple layers. Mapping out the phase diagram shows a linear relationship between the diameters of concentric layers, the slope of which depends on the initial ternary composition and the molecular weight of the surfactant. These general rules quantitatively predict the number of droplet layers (multiplicity), which we used to devise self-assembly routes for polymer capsules and liposomes. Moreover, we extended the technique to the assembly of lipid-stabilized droplets with ordered internal structures.

    Original languageEnglish (US)
    Pages (from-to)11793-11797
    Number of pages5
    JournalAngewandte Chemie - International Edition
    Volume53
    Issue number44
    DOIs
    StatePublished - Oct 27 2014

    Fingerprint

    Emulsions
    Phase separation
    Spinodal decomposition
    Liposomes
    Liquids
    Coalescence
    Drug delivery
    Microfluidics
    Surface-Active Agents
    Self assembly
    Lipids
    Phase diagrams
    Capsules
    Assays
    Polymers
    Surface active agents
    Nucleation
    Mass transfer
    Molecular weight
    Topology

    Keywords

    • Microfluidics
    • Multiple emulsions
    • Phase diagrams
    • Phase separation
    • Surfactants

    ASJC Scopus subject areas

    • Chemistry(all)
    • Catalysis

    Cite this

    Tailoring of high-order multiple emulsions by the liquid-liquid phase separation of ternary mixtures. / Haase, Martin F.; Brujic, Jasna.

    In: Angewandte Chemie - International Edition, Vol. 53, No. 44, 27.10.2014, p. 11793-11797.

    Research output: Contribution to journalArticle

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