Synthesis of the novel trimeric benzamides - Potential inhibitors of protein-protein interactions

Oleg V. Kulikov, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

The synthesis of the family of new non-natural trimeric oligobenzamides (potential inhibitors of protein-protein interactions) bearing the following groups (R = isobutyl, isopropyl, CH 2CONH 2, (CH 2) 4NH 2, benzyl) that mimic different amino acid residues (leucine, valine, asparagine, lysine, phenylalanine) was accomplished through an iterative (n + 1) elongation approach that includes reduction of the NO 2-group (Pd/C, H 2) and subsequent amide coupling in the presence of Mukaiyama's reagent.

Original languageEnglish (US)
Pages (from-to)2454-2461
Number of pages8
JournalRSC Advances
Volume2
Issue number6
DOIs
StatePublished - Mar 14 2012

Fingerprint

Benzamides
Bearings (structural)
Proteins
Asparagine
Valine
Phenylalanine
Amides
Leucine
Lysine
Amino acids
Elongation
Amino Acids

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Synthesis of the novel trimeric benzamides - Potential inhibitors of protein-protein interactions. / Kulikov, Oleg V.; Hamilton, Andrew.

In: RSC Advances, Vol. 2, No. 6, 14.03.2012, p. 2454-2461.

Research output: Contribution to journalArticle

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