Synthesis of a heterotelechelic helical poly(methacrylamide) and its incorporation into a supramolecular triblock copolymer

Ru Deng, Margarita Milton, Scott K. Pomarico, Marcus Weck

Research output: Contribution to journalArticle

Abstract

We report the first heterotelechelic helical poly(methacrylamide) (PMAc) bearing orthogonal supramolecular binding sites on its chain-ends synthesized through a combination of reversible addition-fragmentation chain-transfer (RAFT) polymerization and thiol-bromo "click" chemistry. The heterotelechelic PMAc was assembled with two monotelechelic polymers featuring different secondary structures, namely a coil-like poly(styrene) and a helical poly(isocyanide), resulting in the formation of a coil-helix-helix supramolecular triblock copolymer through orthogonal metal coordination and hydrogen bonding interactions. Triblock assembly was confirmed through 1H NMR spectroscopy, isothermal titration calorimetry (ITC) and viscometry. The individual polymer blocks retained their secondary structures in the final triblock copolymer, as evidenced by circular dichroism (CD) spectroscopy. Our synthetic strategy expands the toolbox of triblock copolymers featuring structural motifs similar to the ones found in proteins and provides the potential for the development of other complex multifunctional polymeric ensembles.

Original languageEnglish (US)
Pages (from-to)5087-5093
Number of pages7
JournalPolymer Chemistry
Volume10
Issue number37
DOIs
StatePublished - Oct 7 2019

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Block copolymers
Polymers
Click Chemistry
Calorimetry
Styrene
Cyanides
Hydrogen Bonding
Circular Dichroism
Sulfhydryl Compounds
Polymerization
Spectrum Analysis
Bearings (structural)
Magnetic Resonance Spectroscopy
Metals
Binding Sites
Circular dichroism spectroscopy
Viscosity measurement
Binding sites
Titration
Nuclear magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

Cite this

Synthesis of a heterotelechelic helical poly(methacrylamide) and its incorporation into a supramolecular triblock copolymer. / Deng, Ru; Milton, Margarita; Pomarico, Scott K.; Weck, Marcus.

In: Polymer Chemistry, Vol. 10, No. 37, 07.10.2019, p. 5087-5093.

Research output: Contribution to journalArticle

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