Synthesis and biological evaluation of (±)-hippolachnin and analogs

Nils Winter, Zeljka Rupcic, Marc Stadler, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

Due its unique structure and its reported potent antifungal activity, the marine polyketide hippolachnin A (1) has attracted much attention in the synthetic community. Herein, we describe the development of a concise, diversifiable and scalable synthesis of the racemic natural product, which serves as a platform for the generation of bioactive analogues. Biological testing of our synthetic material did not confirm the reported antifungal activity of hippolachnin A but unraveled moderate activity against nematodes and microbes.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalJournal of Antibiotics
Volume72
Issue number6
DOIs
StatePublished - Jun 1 2019

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Polyketides
Biological Products
hippolachnin A

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Synthesis and biological evaluation of (±)-hippolachnin and analogs. / Winter, Nils; Rupcic, Zeljka; Stadler, Marc; Trauner, Dirk.

In: Journal of Antibiotics, Vol. 72, No. 6, 01.06.2019, p. 375-383.

Research output: Contribution to journalArticle

Winter, Nils ; Rupcic, Zeljka ; Stadler, Marc ; Trauner, Dirk. / Synthesis and biological evaluation of (±)-hippolachnin and analogs. In: Journal of Antibiotics. 2019 ; Vol. 72, No. 6. pp. 375-383.
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