Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse

Guido Gerig, Ipek Oguz, Sylvain Gouttard, Joohwi Lee, Hongyu An, Weili Lin, Matthew McMurray, Karen Grewen, Josephine Johns, Martin Andreas Styner

    Research output: Contribution to journalArticle

    Abstract

    The use of structural magnetic resonance imaging (sMRI) and diffusion tensor imaging (DTI) in animal models of neuropathology is of increasing interest to the neuroscience community. In this work, we present our approach to create optimal translational studies that include both animal and human neuroimaging data within the frameworks of a study of post-natal neuro-development in intra-uterine cocaine-exposure. We propose the use of non-invasive neuroimaging to study developmental brain structural and white matter pathway abnormalities via sMRI and DTI, as advanced MR imaging technology is readily available and automated image analysis methodology have recently been transferred from the human to animal imaging setting. For this purpose, we developed a synergistic, parallel approach to imaging and image analysis for the human and the rodent branch of our study. We propose an equivalent design in both the selection of the developmental assessment stage and the neuroimaging setup. This approach brings significant advantages to study neurobiological features of early brain development that are common to animals and humans but also preserve analysis capabilities only possible in animal research. This paper presents the main framework and individual methods for the proposed cross-species study design, as well as preliminary DTI cross-species comparative results in the intra-uterine cocaine-exposure study.

    Original languageEnglish (US)
    Article numberArticle 53
    JournalFrontiers in Psychiatry
    Volume2
    Issue numberOCT
    DOIs
    StatePublished - Dec 1 2011

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    Keywords

    • Brain segmentation
    • Diffusion tensor imaging
    • Drug abuse
    • Magnetic resonance imaging
    • Neonatal neuroimaging
    • Small animal imaging
    • White matter pathways

    ASJC Scopus subject areas

    • Psychiatry and Mental health

    Cite this

    Gerig, G., Oguz, I., Gouttard, S., Lee, J., An, H., Lin, W., McMurray, M., Grewen, K., Johns, J., & Styner, M. A. (2011). Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse. Frontiers in Psychiatry, 2(OCT), [Article 53]. https://doi.org/10.3389/fpsyt.2011.00053