Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila

Marcia Simpson-Brose, Jessica Treisman, Claude Desplan

Research output: Contribution to journalArticle

Abstract

Anterior patterning of the Drosophila embryo is specified by the localized expression of the gap genes, which is controlled by the gradient of the maternal morphogen bicoid (bcd). Another maternal component, hunchback (hb), can substitute for bcd in the thorax and abdomen. Here we show that hb is required for bcd to execute all of its functions. Removal of both maternal and zygotic hb produces embryos with disrupted polarity that fail to express all known bcd target genes correctly. Proper expression of hb and the head gap genes requires synergistic activation by hb and bcd. We propose that it is the combined activity of bcd and hb, and not bcd alone, that forms the morphogenetic gradient that specifies polarity along the embryonic axis and patterns the embryo. bcd may be a newly acquired Drosophila gene, which is gradually replacing some of the functions performed by maternal hb in other species.

Original languageEnglish (US)
Pages (from-to)855-865
Number of pages11
JournalCell
Volume78
Issue number5
DOIs
StatePublished - Sep 9 1994

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Drosophila
Genes
Mothers
Embryonic Structures
Abdomen
Thorax
Chemical activation
Head
Gene Expression

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila. / Simpson-Brose, Marcia; Treisman, Jessica; Desplan, Claude.

In: Cell, Vol. 78, No. 5, 09.09.1994, p. 855-865.

Research output: Contribution to journalArticle

Simpson-Brose, Marcia ; Treisman, Jessica ; Desplan, Claude. / Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila. In: Cell. 1994 ; Vol. 78, No. 5. pp. 855-865.
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