Syndemic conditions associated with increased HIV risk in a global sample of men who have sex with men

Glenn Milo Santos, Tri Do, Jack Beck, Keletso Makofane, Sonya Arreola, Thomas Pyun, Pato Hebert, Patrick A. Wilson, George Ayala

Research output: Contribution to journalArticle

Abstract

Objective: We evaluated the relationship among syndemic conditions (defined as a cluster of interconnected psychosocial health conditions), sexual behaviours and self-reported HIV infection in a global sample of men who have sex with men (MSM). Methods: We used generalised estimating equations logistic regression models with robust SEs to assess the relationships among cumulative number of syndemic conditions - including depression, substance use, violence, sexual stigma and homelessness - and unprotected anal intercourse (UAI) and HIV infection, while accounting for clustering within-country in a global cross-sectional survey of 3934 MSM across 151 countries. Results: We observed parallel, significant dose - response associations between the number of syndemic conditions and UAI, as well as number of syndemic conditions and HIV infection. Compared with participants without syndemics, the adjusted OR (aOR) for UAI among those with 1, 2 and 3 or more syndemic conditions were 1.44 (Bonferroni-adjusted 95% CI 1.23 to 1.68), 1.89 (1.51 to 2.36) and 2.03 (1.43 to 2.89), respectively. Compared with participants without syndemics, the aOR for HIV infection among those with 1, 2 and 3 or more syndemic conditions were 1.67 (1.24 to 2.26), 2.02 (1.44 to 2.85) and 2.35 (1.31 to 4.21), respectively. Conclusions: This analysis provides evidence of intertwining syndemics that may operate synergistically to increase HIV risk among MSM globally. To curb HIV effectively and advance the health of MSM, multiple conditions must be addressed concurrently using multi-level approaches that target both individual and structural risk factors.

Original languageEnglish (US)
Pages (from-to)250-253
Number of pages4
JournalSexually Transmitted Infections
Volume90
Issue number3
DOIs
StatePublished - 2014

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HIV Infections
HIV
Logistic Models
Homeless Persons
Sex Offenses
Health
Sexual Behavior
Cluster Analysis
Cross-Sectional Studies
Depression

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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Syndemic conditions associated with increased HIV risk in a global sample of men who have sex with men. / Santos, Glenn Milo; Do, Tri; Beck, Jack; Makofane, Keletso; Arreola, Sonya; Pyun, Thomas; Hebert, Pato; Wilson, Patrick A.; Ayala, George.

In: Sexually Transmitted Infections, Vol. 90, No. 3, 2014, p. 250-253.

Research output: Contribution to journalArticle

Santos, Glenn Milo ; Do, Tri ; Beck, Jack ; Makofane, Keletso ; Arreola, Sonya ; Pyun, Thomas ; Hebert, Pato ; Wilson, Patrick A. ; Ayala, George. / Syndemic conditions associated with increased HIV risk in a global sample of men who have sex with men. In: Sexually Transmitted Infections. 2014 ; Vol. 90, No. 3. pp. 250-253.
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