Synchrotron X-ray imaging via ultra-small-angle scattering: Principles of quantitative analysis and application in studying bone integration to synthetic grafting materials

Sérgio L. Morelhão, Paulo G. Coelho, Marcelo G. Hönnicke

Research output: Contribution to journalArticle


Optimized experimental conditions for extracting accurate information at subpixel length scales from analyzer-based X-ray imaging were obtained and applied to investigate bone regeneration by means of synthetic β-TCP grafting materials in a rat calvaria model. The results showed a 30% growth in the particulate size due to bone ongrowth/ingrowth within the critical size defect over a 1-month healing period.

Original languageEnglish (US)
Pages (from-to)861-865
Number of pages5
JournalEuropean Biophysics Journal
Issue number5
StatePublished - Apr 1 2010



  • Bone
  • Grafting material
  • In vivo
  • Synchrotron
  • Ultra-small-angle scattering

ASJC Scopus subject areas

  • Biophysics

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