Synaptic plasticity/dysplasticity, process memory and item memory in rodent models of mental dysfunction

Kally C. O'Reilly, Maria I. Perica, Andre Fenton

Research output: Contribution to journalArticle

Abstract

Activity-dependent changes in the effective connection strength of synapses are a fundamental feature of a nervous system. This so-called synaptic plasticity is thought to underlie storage of information in memory and has been hypothesized to be crucial for the effects of cognitive behavioral therapy. Synaptic plasticity stores information in a neural network, creating a trace of neural activity from past experience. The plasticity can also change the behavior of the network so the network can differentially transform/compute information in future activations. We discuss these two related but separable functions of synaptic plasticity; one we call “item memory” as it represents and stores items of information in memory, the other we call “process memory” as it encodes and stores functions such as computations to modify network information processing capabilities. We review evidence of item and process memory operations in behavior and evidence that experience modifies the brain's functional networks. We discuss neurodevelopmental rodent models relevant for understanding mental illness and compare two models in which one model, neonatal ventral hippocampal lesion (NVHL) has beneficial adult outcomes after being exposed to an adolescent cognitive experience that is potentially similar to cognitive behavioral therapy. The other model, gestational day 17 methylazoxymethanol acetate (GD17-MAM), does not benefit from the same adolescent cognitive experience. We propose that process memory is altered by early cognitive experience in NVHL rats but not in GD17-MAM rats, and discuss how dysplasticity factors may contribute to the differential adult outcomes after early cognitive experience in the NVHL and MAM models.

Original languageEnglish (US)
JournalSchizophrenia Research
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Neuronal Plasticity
Rodentia
Methylazoxymethanol Acetate
Cognitive Therapy
Information Storage and Retrieval
Automatic Data Processing
Synapses
Nervous System
Brain

Keywords

  • Cognitive behavioral therapy
  • Dysplasticity
  • Hippocampus
  • Neurodevelopment
  • Schizophrenia
  • Synaptic function

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Synaptic plasticity/dysplasticity, process memory and item memory in rodent models of mental dysfunction. / O'Reilly, Kally C.; Perica, Maria I.; Fenton, Andre.

In: Schizophrenia Research, 01.01.2018.

Research output: Contribution to journalArticle

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