Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model

Albert Compte, Nicolas Brunel, Patricia S. Goldman-Rakic, Xiao-Jing Wang

Research output: Contribution to journalArticle

Abstract

Single-neuron recordings from behaving primates have established a link between working memory processes and information-specific neuronal persistent activity in the prefrontal cortex. Using a network model endowed with a columnar architecture and based on the physiological properties of cortical neurons and synapses, we have examined the synaptic mechanisms of selective persistent activity underlying spatial working memory in the prefrontal cortex. Our model reproduces the phenomenology of the oculomotor delayed-response experiment of Funahashi et al. (S. Funahashi, C.J. Bruce and P.S. Goldman-Rakic, Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol 61:331-349, 1989). To observe stable spontaneous and persistent activity, we find that recurrent synaptic excitation should be primarily mediated by NMDA receptors, and that overall recurrent synaptic interactions should be dominated by inhibition. Iso-directional tuning of adjacent pyramidal cells and interneurons can be accounted for by a structured pyramid-to-interneuron connectivity. Robust memory storage against random drift of the tuned persistent activity and against distractors (intervening stimuli during the delay period) may be enhanced by neuromodulation of recurrent synapses. Experimentally testable predictions concerning the neural basis of working memory are discussed.

Original languageEnglish (US)
Pages (from-to)910-923
Number of pages14
JournalCerebral Cortex
Volume10
Issue number9
StatePublished - 2000

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Prefrontal Cortex
Short-Term Memory
Interneurons
Synapses
Neurons
Pyramidal Cells
N-Methyl-D-Aspartate Receptors
Primates
Haplorhini
Spatial Memory

ASJC Scopus subject areas

  • Neuroscience(all)

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Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. / Compte, Albert; Brunel, Nicolas; Goldman-Rakic, Patricia S.; Wang, Xiao-Jing.

In: Cerebral Cortex, Vol. 10, No. 9, 2000, p. 910-923.

Research output: Contribution to journalArticle

Compte, Albert ; Brunel, Nicolas ; Goldman-Rakic, Patricia S. ; Wang, Xiao-Jing. / Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. In: Cerebral Cortex. 2000 ; Vol. 10, No. 9. pp. 910-923.
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