Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease

K D Kistler, J Molleston, A Unalp, S H Abrams, C Behling, J B Schwimmer, Bradley Aouizerat, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Data on the quality of life (QOL) of children with non-alcoholic fatty liver disease (NAFLD) are needed to estimate the true burden of illness in children with NAFLD.

AIM: To characterize QOL and symptoms of children with NAFLD and to compare QOL in children with NAFLD with that in a sample of healthy children.

METHODS: Quality of life and symptoms were assessed in children with biopsy-proven NAFLD enrolled in the NASH Clinical Research Network. PedsQL scores were compared with scores from healthy children. For children with NAFLD, between-group comparisons were made to test associations of demography, histological severity, symptoms and QOL.

RESULTS: A total of 239 children (mean age 12.6 years) were studied. Children with NAFLD had worse total (72.8 vs. 83.8, P < 0.01), physical (77.2 vs. 87.5, P < 0.01) and psychosocial health (70.4 vs. 81.9, P < 0.01) scores compared with healthy children. QOL scores did not significantly differ by histological severity of NAFLD. Fatigue, trouble sleeping and sadness accounted for almost half of the variance in QOL scores. Impaired QOL was present in 39% of children with NAFLD.

CONCLUSIONS: Children with NAFLD have a decrement in QOL. Symptoms were a major determinant of this impairment. Interventions are needed to restore and optimize QOL in children with NAFLD.

Original languageEnglish (US)
Pages (from-to)396-406
Number of pages11
JournalAlimentary pharmacology & therapeutics
Volume31
Issue number3
DOIs
StatePublished - Feb 1 2010

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Quality of Life
Non-alcoholic Fatty Liver Disease
Cost of Illness
Fatigue
Demography
Biopsy
Health

Keywords

  • Adolescent
  • Anthropometry
  • Child
  • Fatigue
  • Fatty Liver
  • Female
  • Humans
  • Male
  • Obesity
  • Prevalence
  • Quality of Life
  • Reference Values
  • Severity of Illness Index
  • Surveys and Questionnaires

Cite this

Kistler, K. D., Molleston, J., Unalp, A., Abrams, S. H., Behling, C., Schwimmer, J. B., ... Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) (2010). Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease. Alimentary pharmacology & therapeutics, 31(3), 396-406. https://doi.org/10.1111/j.1365-2036.2009.04181.x

Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease. / Kistler, K D; Molleston, J; Unalp, A; Abrams, S H; Behling, C; Schwimmer, J B; Aouizerat, Bradley; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN).

In: Alimentary pharmacology & therapeutics, Vol. 31, No. 3, 01.02.2010, p. 396-406.

Research output: Contribution to journalArticle

Kistler, KD, Molleston, J, Unalp, A, Abrams, SH, Behling, C, Schwimmer, JB, Aouizerat, B & Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) 2010, 'Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease', Alimentary pharmacology & therapeutics, vol. 31, no. 3, pp. 396-406. https://doi.org/10.1111/j.1365-2036.2009.04181.x
Kistler, K D ; Molleston, J ; Unalp, A ; Abrams, S H ; Behling, C ; Schwimmer, J B ; Aouizerat, Bradley ; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). / Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease. In: Alimentary pharmacology & therapeutics. 2010 ; Vol. 31, No. 3. pp. 396-406.
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abstract = "BACKGROUND: Data on the quality of life (QOL) of children with non-alcoholic fatty liver disease (NAFLD) are needed to estimate the true burden of illness in children with NAFLD.AIM: To characterize QOL and symptoms of children with NAFLD and to compare QOL in children with NAFLD with that in a sample of healthy children.METHODS: Quality of life and symptoms were assessed in children with biopsy-proven NAFLD enrolled in the NASH Clinical Research Network. PedsQL scores were compared with scores from healthy children. For children with NAFLD, between-group comparisons were made to test associations of demography, histological severity, symptoms and QOL.RESULTS: A total of 239 children (mean age 12.6 years) were studied. Children with NAFLD had worse total (72.8 vs. 83.8, P < 0.01), physical (77.2 vs. 87.5, P < 0.01) and psychosocial health (70.4 vs. 81.9, P < 0.01) scores compared with healthy children. QOL scores did not significantly differ by histological severity of NAFLD. Fatigue, trouble sleeping and sadness accounted for almost half of the variance in QOL scores. Impaired QOL was present in 39{\%} of children with NAFLD.CONCLUSIONS: Children with NAFLD have a decrement in QOL. Symptoms were a major determinant of this impairment. Interventions are needed to restore and optimize QOL in children with NAFLD.",
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AU - Kistler, K D

AU - Molleston, J

AU - Unalp, A

AU - Abrams, S H

AU - Behling, C

AU - Schwimmer, J B

AU - Aouizerat, Bradley

AU - Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)

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N2 - BACKGROUND: Data on the quality of life (QOL) of children with non-alcoholic fatty liver disease (NAFLD) are needed to estimate the true burden of illness in children with NAFLD.AIM: To characterize QOL and symptoms of children with NAFLD and to compare QOL in children with NAFLD with that in a sample of healthy children.METHODS: Quality of life and symptoms were assessed in children with biopsy-proven NAFLD enrolled in the NASH Clinical Research Network. PedsQL scores were compared with scores from healthy children. For children with NAFLD, between-group comparisons were made to test associations of demography, histological severity, symptoms and QOL.RESULTS: A total of 239 children (mean age 12.6 years) were studied. Children with NAFLD had worse total (72.8 vs. 83.8, P < 0.01), physical (77.2 vs. 87.5, P < 0.01) and psychosocial health (70.4 vs. 81.9, P < 0.01) scores compared with healthy children. QOL scores did not significantly differ by histological severity of NAFLD. Fatigue, trouble sleeping and sadness accounted for almost half of the variance in QOL scores. Impaired QOL was present in 39% of children with NAFLD.CONCLUSIONS: Children with NAFLD have a decrement in QOL. Symptoms were a major determinant of this impairment. Interventions are needed to restore and optimize QOL in children with NAFLD.

AB - BACKGROUND: Data on the quality of life (QOL) of children with non-alcoholic fatty liver disease (NAFLD) are needed to estimate the true burden of illness in children with NAFLD.AIM: To characterize QOL and symptoms of children with NAFLD and to compare QOL in children with NAFLD with that in a sample of healthy children.METHODS: Quality of life and symptoms were assessed in children with biopsy-proven NAFLD enrolled in the NASH Clinical Research Network. PedsQL scores were compared with scores from healthy children. For children with NAFLD, between-group comparisons were made to test associations of demography, histological severity, symptoms and QOL.RESULTS: A total of 239 children (mean age 12.6 years) were studied. Children with NAFLD had worse total (72.8 vs. 83.8, P < 0.01), physical (77.2 vs. 87.5, P < 0.01) and psychosocial health (70.4 vs. 81.9, P < 0.01) scores compared with healthy children. QOL scores did not significantly differ by histological severity of NAFLD. Fatigue, trouble sleeping and sadness accounted for almost half of the variance in QOL scores. Impaired QOL was present in 39% of children with NAFLD.CONCLUSIONS: Children with NAFLD have a decrement in QOL. Symptoms were a major determinant of this impairment. Interventions are needed to restore and optimize QOL in children with NAFLD.

KW - Adolescent

KW - Anthropometry

KW - Child

KW - Fatigue

KW - Fatty Liver

KW - Female

KW - Humans

KW - Male

KW - Obesity

KW - Prevalence

KW - Quality of Life

KW - Reference Values

KW - Severity of Illness Index

KW - Surveys and Questionnaires

U2 - 10.1111/j.1365-2036.2009.04181.x

DO - 10.1111/j.1365-2036.2009.04181.x

M3 - Article

VL - 31

SP - 396

EP - 406

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

SN - 0269-2813

IS - 3

ER -