Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase

Habibul Ahsan, Yu Chen, Muhammad G. Kibriya, Mohammad N. Islam, Vesna N. Slavkovich, Joseph H. Graziano, Regina M. Santella

Research output: Contribution to journalArticle

Abstract

Chronic exposure to inorganic arsenic is known to cause non-melanocytic skin and internal cancers in humans. We examined whether genetic susceptibility, as determined by single nucleotide polymorphisms -463G→A and -262C→T in the oxidative stress genes myeloperoxidase (MPO) and catalase (CAT), respectively, are associated with the risk of arsenic-induced hyperkeratotic skin lesions - precursors of skin cancer - in a case-control study in Bangladesh. Carriers of the susceptible MPO and CAT genotypes were at elevated risk (OR 2.1 and 95% CI 0.7-6.2 for MPO; OR 1.9 and 95% CI 0.8-4.7 for CAT) of hyperkeratosis after adjustment for arsenic exposure and other covariates. Subjects carrying the high-risk MPO genotype and with high arsenic exposure were at almost six times (OR 5.8; 95% CI 1.1-30.1) elevated risk of developing hyperkeratosis as compared to those carrying the low-risk genotype and with low arsenic exposure. Similarly, highly exposed subjects carrying the high-risk CAT genotype were at more than four times (OR 4.6; 95% CI 1.4-15.6) elevated risk of developing hyperkeratosis as compared to those carrying the low-risk genotype and with low arsenic exposure. Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions.

Original languageEnglish (US)
Pages (from-to)57-65
Number of pages9
JournalCancer Letters
Volume201
Issue number1
DOIs
StatePublished - Nov 10 2003

Fingerprint

Arsenic
Catalase
Peroxidase
Oxidative Stress
Genes
Genotype
Skin Neoplasms
Skin
Bangladesh
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
Case-Control Studies

Keywords

  • Arsenic
  • CAT
  • Gene-environmental interaction
  • Genetic susceptibility
  • MPO
  • Oxidative stress genes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Ahsan, H., Chen, Y., Kibriya, M. G., Islam, M. N., Slavkovich, V. N., Graziano, J. H., & Santella, R. M. (2003). Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase. Cancer Letters, 201(1), 57-65. https://doi.org/10.1016/S0304-3835(03)00471-3

Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase. / Ahsan, Habibul; Chen, Yu; Kibriya, Muhammad G.; Islam, Mohammad N.; Slavkovich, Vesna N.; Graziano, Joseph H.; Santella, Regina M.

In: Cancer Letters, Vol. 201, No. 1, 10.11.2003, p. 57-65.

Research output: Contribution to journalArticle

Ahsan, H, Chen, Y, Kibriya, MG, Islam, MN, Slavkovich, VN, Graziano, JH & Santella, RM 2003, 'Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase', Cancer Letters, vol. 201, no. 1, pp. 57-65. https://doi.org/10.1016/S0304-3835(03)00471-3
Ahsan, Habibul ; Chen, Yu ; Kibriya, Muhammad G. ; Islam, Mohammad N. ; Slavkovich, Vesna N. ; Graziano, Joseph H. ; Santella, Regina M. / Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase. In: Cancer Letters. 2003 ; Vol. 201, No. 1. pp. 57-65.
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AB - Chronic exposure to inorganic arsenic is known to cause non-melanocytic skin and internal cancers in humans. We examined whether genetic susceptibility, as determined by single nucleotide polymorphisms -463G→A and -262C→T in the oxidative stress genes myeloperoxidase (MPO) and catalase (CAT), respectively, are associated with the risk of arsenic-induced hyperkeratotic skin lesions - precursors of skin cancer - in a case-control study in Bangladesh. Carriers of the susceptible MPO and CAT genotypes were at elevated risk (OR 2.1 and 95% CI 0.7-6.2 for MPO; OR 1.9 and 95% CI 0.8-4.7 for CAT) of hyperkeratosis after adjustment for arsenic exposure and other covariates. Subjects carrying the high-risk MPO genotype and with high arsenic exposure were at almost six times (OR 5.8; 95% CI 1.1-30.1) elevated risk of developing hyperkeratosis as compared to those carrying the low-risk genotype and with low arsenic exposure. Similarly, highly exposed subjects carrying the high-risk CAT genotype were at more than four times (OR 4.6; 95% CI 1.4-15.6) elevated risk of developing hyperkeratosis as compared to those carrying the low-risk genotype and with low arsenic exposure. Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions.

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