Surface vs. solution hybridization: Effects of salt, temperature, and probe type

Wanqiong Qiao, Hao Chun Chiang, Hui Xie, Rastislav Levicky

Research output: Contribution to journalArticle


Hybridization thermodynamics on solid supports are compared with those in solution for two types of hybridization probe, DNA and uncharged morpholino oligonucleotides of identical sequences. Trends in hybridization affinity are discussed with respect to ionic strength, temperature, and surface behavior.

Original languageEnglish (US)
Pages (from-to)17245-17248
Number of pages4
JournalChemical Communications
Issue number97
StatePublished - Oct 1 2015


ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this