Surface recognition and helix stabilization of a tetraaspartate peptide by shape and electrostatic complementarity of an artificial receptor

Thomas Haack, Mark W. Peczuh, Xavier Salvatella, Jorge Sánchez-Quesada, Javier De Mendoza, Andrew D. Hamilton, Ernest Giralt

Research output: Contribution to journalArticle


The recognition of tetraaspartate peptide (2) by tetra-guanidinium (1) in (a) water and (b) aqueous methanol (10% H2O/90% CH3OH) has been investigated. The conformations of the free peptide and its complex with 1 have been characterized in both solvent systems by CD and 2D NMR spectroscopies. Increased α-helicity as a result of solvent composition and receptor binding are discussed. Control experiments show that the recognition stems from complementary electrostatic interactions, hydrogen bonding, and matching of surface topologies.

Original languageEnglish (US)
Pages (from-to)11813-11820
Number of pages8
JournalJournal of the American Chemical Society
Issue number50
StatePublished - Dec 22 1999


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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