Sulfadiazines reduce gingivitis and plaque formation in beagle dogs

T. H. Howell, M. S. Reddy, H. P. Weber, K. L. Li, M. C. Alfano, Richard Vogel, A. C R Tanner, R. C. Williams

Research output: Contribution to journalArticle

Abstract

The effect of zinc sulfadiazine (ZnSD) and silver sulfadiazine (AgSD) on reducing plaque formation and gingivitis was studied in 12 beagle dogs over a 14-week period. 12 Beagle dogs were scaled, root planed and pumices to bring them to a similar level of gingival health, prior to placing them on a diet of Purina Dog Chow softened with canned gravy and molasses to promote the build-up of plaque and the initiation of gingivitis. At the end of 8 weeks, the dogs were determined to have substantial bacterial plaque accumulation and apparent gingivitis. Thereafter, 4 dogs were treated 2x daily with topical applictions of 3% zinc sulfadiazine; 4 dogs were treated with 2% silver sulfadiazine while 4 dogs were treated with placebo gel serving as control over a 14-week treatment period. By week 2, the zinc and silver sulfadiazine dogs showed a significant decrease in gingival index which was maintained throughout the study. Additionally, by week 2, the % of sites with bleeding was also seen to decrease significantly in the experimental groups. The plaque index remained consistent in all 3 groups until week 6 when the 2 experimental groups indicated significant decrease in plaque accumulation as compared to controls. Probing depths were also seen to decrease significantly in the experimental groups after 10 weeks of therapy. The mean stain index was similar in all 3 groups of dogs throughout the study. Data indicate that both zinc and silver sulfadiazine inhibit plaque formation and reduce existing gingivitis in beagle dogs.

Original languageEnglish (US)
Pages (from-to)734-737
Number of pages4
JournalJournal of Clinical Periodontology
Volume17
Issue number10
StatePublished - 1990

Fingerprint

Sulfadiazine
Gingivitis
Dogs
Silver Sulfadiazine
Molasses
Periodontal Index
Health Status
Coloring Agents
Gels
Placebos
Hemorrhage
Diet

Keywords

  • Gingivitis
  • Plaque
  • Sulfadiazines

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Howell, T. H., Reddy, M. S., Weber, H. P., Li, K. L., Alfano, M. C., Vogel, R., ... Williams, R. C. (1990). Sulfadiazines reduce gingivitis and plaque formation in beagle dogs. Journal of Clinical Periodontology, 17(10), 734-737.

Sulfadiazines reduce gingivitis and plaque formation in beagle dogs. / Howell, T. H.; Reddy, M. S.; Weber, H. P.; Li, K. L.; Alfano, M. C.; Vogel, Richard; Tanner, A. C R; Williams, R. C.

In: Journal of Clinical Periodontology, Vol. 17, No. 10, 1990, p. 734-737.

Research output: Contribution to journalArticle

Howell, TH, Reddy, MS, Weber, HP, Li, KL, Alfano, MC, Vogel, R, Tanner, ACR & Williams, RC 1990, 'Sulfadiazines reduce gingivitis and plaque formation in beagle dogs', Journal of Clinical Periodontology, vol. 17, no. 10, pp. 734-737.
Howell TH, Reddy MS, Weber HP, Li KL, Alfano MC, Vogel R et al. Sulfadiazines reduce gingivitis and plaque formation in beagle dogs. Journal of Clinical Periodontology. 1990;17(10):734-737.
Howell, T. H. ; Reddy, M. S. ; Weber, H. P. ; Li, K. L. ; Alfano, M. C. ; Vogel, Richard ; Tanner, A. C R ; Williams, R. C. / Sulfadiazines reduce gingivitis and plaque formation in beagle dogs. In: Journal of Clinical Periodontology. 1990 ; Vol. 17, No. 10. pp. 734-737.
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