Sulfadiazines prevent plaque formation and gingivitis in beagles

T. H. Howell, M. S. Reddy, H. P. Weber, K. L. Li, M. C. Alfano, Richard Vogel, A. C R Tanner, R. C. Williams

Research output: Contribution to journalArticle

Abstract

The effect of zinc sulfadiazine (ZnSD) and silver sulfadiazine (AgSD) on developing plaque formation and gingivitis was studied in 12 beagle dogs over a 14-week period. Plaque and gingival indices were used to measure plaque formation and gingivitis. During a 2-wk baseline period each dog was brought to optimal gingival health with prophylaxis and tooth brushing. Thereafter, 4 dogs were treated twice daily with topical application of 3.0% zinc sulfadiazine; 4 dogs were treated with 2.0% silver sulfadiazine while 4 dogs treated with placebo gel served as controls over a 12-wk treatment period. At wk 2 of treatment, all three groups of dogs showed an increase in plaque build-up on their teeth from baseline. By wk 6, plaque accumulation on the teeth was significantly less in dogs treated with either ZnSD or AgSD compared to control dogs. At wk 2 of treatment, gingival inflammation was increased from baseline in all three groups. Thereafter, over the course of the 12-wk treatment period, gingival inflammation in the ZnSD and the AgSD treated dogs was significantly less than the placebo treated dogs. The data indicate that both ZnSD and AgSD inhibit developing plaque formation in beagles. This significant inhibition of plaque formation was accompanied by a significant reduction in gingival inflamation.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalJournal of Periodontal Research
Volume25
Issue number4
StatePublished - 1990

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Sulfadiazine
Gingivitis
Dogs
Silver Sulfadiazine
Tooth
Placebos
Inflammation
Periodontal Index
Therapeutics
Gels

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Howell, T. H., Reddy, M. S., Weber, H. P., Li, K. L., Alfano, M. C., Vogel, R., ... Williams, R. C. (1990). Sulfadiazines prevent plaque formation and gingivitis in beagles. Journal of Periodontal Research, 25(4), 197-200.

Sulfadiazines prevent plaque formation and gingivitis in beagles. / Howell, T. H.; Reddy, M. S.; Weber, H. P.; Li, K. L.; Alfano, M. C.; Vogel, Richard; Tanner, A. C R; Williams, R. C.

In: Journal of Periodontal Research, Vol. 25, No. 4, 1990, p. 197-200.

Research output: Contribution to journalArticle

Howell, TH, Reddy, MS, Weber, HP, Li, KL, Alfano, MC, Vogel, R, Tanner, ACR & Williams, RC 1990, 'Sulfadiazines prevent plaque formation and gingivitis in beagles', Journal of Periodontal Research, vol. 25, no. 4, pp. 197-200.
Howell TH, Reddy MS, Weber HP, Li KL, Alfano MC, Vogel R et al. Sulfadiazines prevent plaque formation and gingivitis in beagles. Journal of Periodontal Research. 1990;25(4):197-200.
Howell, T. H. ; Reddy, M. S. ; Weber, H. P. ; Li, K. L. ; Alfano, M. C. ; Vogel, Richard ; Tanner, A. C R ; Williams, R. C. / Sulfadiazines prevent plaque formation and gingivitis in beagles. In: Journal of Periodontal Research. 1990 ; Vol. 25, No. 4. pp. 197-200.
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