Sugary food and beverage consumption and epithelial ovarian cancer risk

A population-based case-control study

Melony G. King, Sara H. Olson, Lisa Paddock, Urmila Chandran, Kitaw Demissie, Shou En Lu, Niyati Parekh, Lorna Rodriguez-Rodriguez, Elisa V. Bandera

Research output: Contribution to journalArticle

Abstract

Background: Ovarian cancer is the deadliest gynecologic cancer in the US. The consumption of refined sugars has increased dramatically over the past few decades, accounting for almost 15% of total energy intake. Yet, there is limited evidence on how sugar consumption affects ovarian cancer risk.Methods: We evaluated ovarian cancer risk in relation to sugary foods and beverages, and total and added sugar intakes in a population-based case-control study. Cases were women with newly diagnosed epithelial ovarian cancer, older than 21 years, able to speak English or Spanish, and residents of six counties in New Jersey. Controls met same criteria as cases, but were ineligible if they had both ovaries removed. A total of 205 cases and 390 controls completed a phone interview, food frequency questionnaire, and self-recorded waist and hip measurements. Based on dietary data, we computed the number of servings of dessert foods, non-dessert foods, sugary drinks and total sugary foods and drinks for each participant. Total and added sugar intakes (grams/day) were also calculated. Multiple logistic regression models were used to estimate odds ratios and 95% confidence intervals for food and drink groups and total and added sugar intakes, while adjusting for major risk factors.Results: We did not find evidence of an association between consumption of sugary foods and beverages and risk, although there was a suggestion of increased risk associated with sugary drink intake (servings per 1,000 kcal; OR=1.63, 95% CI: 0.94-2.83).Conclusions: Overall, we found little indication that sugar intake played a major role on ovarian cancer development.

Original languageEnglish (US)
Article number94
JournalBMC Cancer
Volume13
DOIs
StatePublished - Feb 27 2013

Fingerprint

Food and Beverages
Case-Control Studies
Ovarian Neoplasms
Food
Population
Logistic Models
Energy Intake
Hip
Ovary
Odds Ratio
Ovarian epithelial cancer
Confidence Intervals
Interviews
Neoplasms

Keywords

  • Added sugars
  • Caloric sweeteners
  • Case-control
  • Diet
  • Nutrition
  • Ovarian cancer
  • Risk factors
  • Sugar
  • Sugary drinks
  • Sugary foods

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

King, M. G., Olson, S. H., Paddock, L., Chandran, U., Demissie, K., Lu, S. E., ... Bandera, E. V. (2013). Sugary food and beverage consumption and epithelial ovarian cancer risk: A population-based case-control study. BMC Cancer, 13, [94]. https://doi.org/10.1186/1471-2407-13-94

Sugary food and beverage consumption and epithelial ovarian cancer risk : A population-based case-control study. / King, Melony G.; Olson, Sara H.; Paddock, Lisa; Chandran, Urmila; Demissie, Kitaw; Lu, Shou En; Parekh, Niyati; Rodriguez-Rodriguez, Lorna; Bandera, Elisa V.

In: BMC Cancer, Vol. 13, 94, 27.02.2013.

Research output: Contribution to journalArticle

King, MG, Olson, SH, Paddock, L, Chandran, U, Demissie, K, Lu, SE, Parekh, N, Rodriguez-Rodriguez, L & Bandera, EV 2013, 'Sugary food and beverage consumption and epithelial ovarian cancer risk: A population-based case-control study', BMC Cancer, vol. 13, 94. https://doi.org/10.1186/1471-2407-13-94
King, Melony G. ; Olson, Sara H. ; Paddock, Lisa ; Chandran, Urmila ; Demissie, Kitaw ; Lu, Shou En ; Parekh, Niyati ; Rodriguez-Rodriguez, Lorna ; Bandera, Elisa V. / Sugary food and beverage consumption and epithelial ovarian cancer risk : A population-based case-control study. In: BMC Cancer. 2013 ; Vol. 13.
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abstract = "Background: Ovarian cancer is the deadliest gynecologic cancer in the US. The consumption of refined sugars has increased dramatically over the past few decades, accounting for almost 15{\%} of total energy intake. Yet, there is limited evidence on how sugar consumption affects ovarian cancer risk.Methods: We evaluated ovarian cancer risk in relation to sugary foods and beverages, and total and added sugar intakes in a population-based case-control study. Cases were women with newly diagnosed epithelial ovarian cancer, older than 21 years, able to speak English or Spanish, and residents of six counties in New Jersey. Controls met same criteria as cases, but were ineligible if they had both ovaries removed. A total of 205 cases and 390 controls completed a phone interview, food frequency questionnaire, and self-recorded waist and hip measurements. Based on dietary data, we computed the number of servings of dessert foods, non-dessert foods, sugary drinks and total sugary foods and drinks for each participant. Total and added sugar intakes (grams/day) were also calculated. Multiple logistic regression models were used to estimate odds ratios and 95{\%} confidence intervals for food and drink groups and total and added sugar intakes, while adjusting for major risk factors.Results: We did not find evidence of an association between consumption of sugary foods and beverages and risk, although there was a suggestion of increased risk associated with sugary drink intake (servings per 1,000 kcal; OR=1.63, 95{\%} CI: 0.94-2.83).Conclusions: Overall, we found little indication that sugar intake played a major role on ovarian cancer development.",
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KW - Risk factors

KW - Sugar

KW - Sugary drinks

KW - Sugary foods

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