Subcortical Structures in Aphasia: An Analysis Based on (F-18)-Fluorodeoxyglucose, Positron Emission Tomography, and Computed Tomography

E. Jeffrey Metter, Walter H. Riege, Wayne R. Hanson, Catherine A. Jackson, Daniel Kempler, Diana Van Lancker

Research output: Contribution to journalArticle


Subcortical structural damage that includes the anterior and posterior internal capsule, caudate, thalamus, lenticular nuclei, and insula has been shown to cause aphasias. A critical question that has not been resolved is whether the role of these structures on behavior is a direct one or whether it is indirect through the cortex. We have used pathway analysis to evaluate computed tomography, glucose metabolic, and language data from 47 aphasic patients to answer this question. For fluency (from the Western Aphasia Battery), subcortical structural damage had direct and indirect (through frontal lobe) effects on the behavior. For a comprehension task (sequential commands), subcortical damage had no direct effect and only a slight indirect effect through the temporal lobe. Thus, both direct and indirect effects of subcortical damage can be demonstrated for specific behavioral measures.

Original languageEnglish (US)
Pages (from-to)1229-1234
Number of pages6
JournalArchives of Neurology
Issue number11
StatePublished - Nov 1988


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this