Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens

Andrew F. MacAskill, Justin P. Little, John M. Cassel, Adam Carter

Research output: Contribution to journalArticle

Abstract

We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.

Original languageEnglish (US)
Pages (from-to)1624-1626
Number of pages3
JournalNature Neuroscience
Volume15
Issue number12
DOIs
StatePublished - Dec 2012

Fingerprint

Nucleus Accumbens
Neurons
Dendrites
Thalamus
Action Potentials
Hippocampus
Spine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens. / MacAskill, Andrew F.; Little, Justin P.; Cassel, John M.; Carter, Adam.

In: Nature Neuroscience, Vol. 15, No. 12, 12.2012, p. 1624-1626.

Research output: Contribution to journalArticle

MacAskill, Andrew F. ; Little, Justin P. ; Cassel, John M. ; Carter, Adam. / Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens. In: Nature Neuroscience. 2012 ; Vol. 15, No. 12. pp. 1624-1626.
@article{bf4538a8d33e4f5eaf7de55070d24404,
title = "Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens",
abstract = "We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.",
author = "MacAskill, {Andrew F.} and Little, {Justin P.} and Cassel, {John M.} and Adam Carter",
year = "2012",
month = "12",
doi = "10.1038/nn.3254",
language = "English (US)",
volume = "15",
pages = "1624--1626",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens

AU - MacAskill, Andrew F.

AU - Little, Justin P.

AU - Cassel, John M.

AU - Carter, Adam

PY - 2012/12

Y1 - 2012/12

N2 - We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.

AB - We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.

UR - http://www.scopus.com/inward/record.url?scp=84870564101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870564101&partnerID=8YFLogxK

U2 - 10.1038/nn.3254

DO - 10.1038/nn.3254

M3 - Article

C2 - 23143514

AN - SCOPUS:84870564101

VL - 15

SP - 1624

EP - 1626

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 12

ER -