Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women

Jeffrey B. Payne, Julie A. Stoner, Pirkka V. Nummikoski, Richard A. Reinhardt, Arthur D. Goren, Mark Wolff, Hsi Ming Lee, James C. Lynch, Robert Valente, Lorne M. Golub

Research output: Contribution to journalArticle

Abstract

Aim: Determine the efficacy of 2-year continuous subantimicrobial dose doxycycline (SDD; 20 mg bid) on alveolar bone in post-menopausal osteopenic, oestrogen-deficient women undergoing periodontal maintenance in a 2-year double-blind, placebo-controlled, randomized clinical trial. Material and Methods: One-hundred and twenty-eight subjects randomized to SDD or placebo (n=64 each). Posterior vertical bite wings taken at baseline, 1 and 2 years for alveolar bone density (ABD), using radiographic absorptiometry (RA) and computer-assisted densitometric image analysis (CADIA), and alveolar bone height (ABH). Statistical analyses utilized generalized estimating equations; primary analyses were intent to treat (ITT). Results are presented as SDD versus placebo. Results: Under ITT, there was no statistically significant effect of SDD on ABD loss (RA: p=0.8; CADIA: p=0.2) or ABH loss (p=0.2). Most sites (81-95%) were inactive. For subgroup analyses, mean CADIA was higher with SDD for non-smokers (p=0.05) and baseline probing depths ≥5 mm (p=0.003). SDD was associated with 29% lower odds of more progressive ABH loss in women >5 years post-menopausal (p=0.05) and 36% lower among protocol-adherent subjects (p=0.03). Conclusions: In post-menopausal osteopenic women with periodontitis, SDD did not differ overall from placebo. Based on exploratory subgroup analyses, additional research is needed to determine the usefulness of SDD in non-smokers, subjects >5 years post-menopausal and in deeper pockets.Protocol registered at ClinicalTrials.gov. Identifier: NCT00066027

Original languageEnglish (US)
Pages (from-to)776-787
Number of pages12
JournalJournal of Clinical Periodontology
Volume34
Issue number9
DOIs
StatePublished - Sep 2007

Fingerprint

Alveolar Bone Loss
Doxycycline
Computer-Assisted Image Processing
Placebos
Bone Density
Bone and Bones
Periodontitis
Bites and Stings
Estrogens
Randomized Controlled Trials
Maintenance
Research

Keywords

  • Computer-assisted densitometric image analysis (CADIA)
  • Dual-energy X-ray absorptiometry (DEXA)
  • Osteopenia
  • Periodontal maintenance
  • Periodontitis
  • Post-menopausal
  • Radiographic absorptiometry (RA) method
  • Randomized clinical trial

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Payne, J. B., Stoner, J. A., Nummikoski, P. V., Reinhardt, R. A., Goren, A. D., Wolff, M., ... Golub, L. M. (2007). Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women. Journal of Clinical Periodontology, 34(9), 776-787. https://doi.org/10.1111/j.1600-051X.2007.01115.x

Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women. / Payne, Jeffrey B.; Stoner, Julie A.; Nummikoski, Pirkka V.; Reinhardt, Richard A.; Goren, Arthur D.; Wolff, Mark; Lee, Hsi Ming; Lynch, James C.; Valente, Robert; Golub, Lorne M.

In: Journal of Clinical Periodontology, Vol. 34, No. 9, 09.2007, p. 776-787.

Research output: Contribution to journalArticle

Payne, JB, Stoner, JA, Nummikoski, PV, Reinhardt, RA, Goren, AD, Wolff, M, Lee, HM, Lynch, JC, Valente, R & Golub, LM 2007, 'Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women', Journal of Clinical Periodontology, vol. 34, no. 9, pp. 776-787. https://doi.org/10.1111/j.1600-051X.2007.01115.x
Payne, Jeffrey B. ; Stoner, Julie A. ; Nummikoski, Pirkka V. ; Reinhardt, Richard A. ; Goren, Arthur D. ; Wolff, Mark ; Lee, Hsi Ming ; Lynch, James C. ; Valente, Robert ; Golub, Lorne M. / Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women. In: Journal of Clinical Periodontology. 2007 ; Vol. 34, No. 9. pp. 776-787.
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abstract = "Aim: Determine the efficacy of 2-year continuous subantimicrobial dose doxycycline (SDD; 20 mg bid) on alveolar bone in post-menopausal osteopenic, oestrogen-deficient women undergoing periodontal maintenance in a 2-year double-blind, placebo-controlled, randomized clinical trial. Material and Methods: One-hundred and twenty-eight subjects randomized to SDD or placebo (n=64 each). Posterior vertical bite wings taken at baseline, 1 and 2 years for alveolar bone density (ABD), using radiographic absorptiometry (RA) and computer-assisted densitometric image analysis (CADIA), and alveolar bone height (ABH). Statistical analyses utilized generalized estimating equations; primary analyses were intent to treat (ITT). Results are presented as SDD versus placebo. Results: Under ITT, there was no statistically significant effect of SDD on ABD loss (RA: p=0.8; CADIA: p=0.2) or ABH loss (p=0.2). Most sites (81-95{\%}) were inactive. For subgroup analyses, mean CADIA was higher with SDD for non-smokers (p=0.05) and baseline probing depths ≥5 mm (p=0.003). SDD was associated with 29{\%} lower odds of more progressive ABH loss in women >5 years post-menopausal (p=0.05) and 36{\%} lower among protocol-adherent subjects (p=0.03). Conclusions: In post-menopausal osteopenic women with periodontitis, SDD did not differ overall from placebo. Based on exploratory subgroup analyses, additional research is needed to determine the usefulness of SDD in non-smokers, subjects >5 years post-menopausal and in deeper pockets.Protocol registered at ClinicalTrials.gov. Identifier: NCT00066027",
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AU - Goren, Arthur D.

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