Studies toward the biomimetic total synthesis of (-)-PF-1018

Robert Webster, Boris Gaspar, Peter Mayer, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

Pericyclic reaction cascades are unparalleled in their ability to quickly generate complex structures with excellent stereocontrol. Herein, the use of a biomimetic Stille/8π electrocyclization/Diels-Alder cascade to successfully assemble the core structure of (-)-PF-1018 is reported.

Original languageEnglish (US)
Pages (from-to)1866-1869
Number of pages4
JournalOrganic Letters
Volume15
Issue number8
DOIs
StatePublished - Apr 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Webster, R., Gaspar, B., Mayer, P., & Trauner, D. (2013). Studies toward the biomimetic total synthesis of (-)-PF-1018. Organic Letters, 15(8), 1866-1869. https://doi.org/10.1021/ol400508s