Studies on the conformation and dynamics of the C8-substituted guanlne adduct of the carcinogen acetytaminofluorene; model for a possible Z-DNA modified structure

Stephen Neidle, Reiko Kuroda, Suse Broyde, Brian E. Hingerty, Robert A. Levine, Dwight W. Miller, Frederick E. Evans

Research output: Contribution to journalArticle

Abstract

The structure of an adduct between guanine and the carcinogen acetylaminofluorene has been examined in the solid state by X-ray crystallography, and in solution by NMR techniques. The observed conformations have been compared with predictions from energy calculations and their relevance to models of adducts with DNA has been examined.

Original languageEnglish (US)
Pages (from-to)8219-8233
Number of pages15
JournalNucleic Acids Research
Volume12
Issue number21
DOIs
StatePublished - Nov 12 1984

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Z-Form DNA
2-Acetylaminofluorene
Carcinogens
DNA Adducts
X ray crystallography
X Ray Crystallography
Guanine
Conformation
Conformations
DNA
Nuclear magnetic resonance
Prediction
Energy
Model
Relevance

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Studies on the conformation and dynamics of the C8-substituted guanlne adduct of the carcinogen acetytaminofluorene; model for a possible Z-DNA modified structure. / Neidle, Stephen; Kuroda, Reiko; Broyde, Suse; Hingerty, Brian E.; Levine, Robert A.; Miller, Dwight W.; Evans, Frederick E.

In: Nucleic Acids Research, Vol. 12, No. 21, 12.11.1984, p. 8219-8233.

Research output: Contribution to journalArticle

Neidle, Stephen ; Kuroda, Reiko ; Broyde, Suse ; Hingerty, Brian E. ; Levine, Robert A. ; Miller, Dwight W. ; Evans, Frederick E. / Studies on the conformation and dynamics of the C8-substituted guanlne adduct of the carcinogen acetytaminofluorene; model for a possible Z-DNA modified structure. In: Nucleic Acids Research. 1984 ; Vol. 12, No. 21. pp. 8219-8233.
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