Structure, function and evolution of multidomain proteins

Christine Vogel, Matthew Bashton, Nicola D. Kerrison, Cyrus Chothia, Sarah A. Teichmann

Research output: Contribution to journalArticle

Abstract

Proteins are composed of evolutionary units called domains; the majority of proteins consist of at least two domains. These domains and nature of their interactions determine the function of the protein. The roles that combinations of domains play in the formation of the protein repertoire have been found by analysis of domain assignments to genome sequences. Additional findings on the geometry of domains have been gained from examination of three-dimensional protein structures. Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations.

Original languageEnglish (US)
Pages (from-to)208-216
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume14
Issue number2
DOIs
StatePublished - Apr 2004

Fingerprint

Proteins
Genome

Keywords

  • PDB
  • Protein Data Bank
  • RMSD
  • Root mean square deviation
  • SCOP
  • SH
  • Src homology
  • Structural Classification of Proteins
  • WHD
  • Winged helix domain

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

Structure, function and evolution of multidomain proteins. / Vogel, Christine; Bashton, Matthew; Kerrison, Nicola D.; Chothia, Cyrus; Teichmann, Sarah A.

In: Current Opinion in Structural Biology, Vol. 14, No. 2, 04.2004, p. 208-216.

Research output: Contribution to journalArticle

Vogel, C, Bashton, M, Kerrison, ND, Chothia, C & Teichmann, SA 2004, 'Structure, function and evolution of multidomain proteins', Current Opinion in Structural Biology, vol. 14, no. 2, pp. 208-216. https://doi.org/10.1016/j.sbi.2004.03.011
Vogel, Christine ; Bashton, Matthew ; Kerrison, Nicola D. ; Chothia, Cyrus ; Teichmann, Sarah A. / Structure, function and evolution of multidomain proteins. In: Current Opinion in Structural Biology. 2004 ; Vol. 14, No. 2. pp. 208-216.
@article{af42193f63914553a7863453b8cf7064,
title = "Structure, function and evolution of multidomain proteins",
abstract = "Proteins are composed of evolutionary units called domains; the majority of proteins consist of at least two domains. These domains and nature of their interactions determine the function of the protein. The roles that combinations of domains play in the formation of the protein repertoire have been found by analysis of domain assignments to genome sequences. Additional findings on the geometry of domains have been gained from examination of three-dimensional protein structures. Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations.",
keywords = "PDB, Protein Data Bank, RMSD, Root mean square deviation, SCOP, SH, Src homology, Structural Classification of Proteins, WHD, Winged helix domain",
author = "Christine Vogel and Matthew Bashton and Kerrison, {Nicola D.} and Cyrus Chothia and Teichmann, {Sarah A.}",
year = "2004",
month = "4",
doi = "10.1016/j.sbi.2004.03.011",
language = "English (US)",
volume = "14",
pages = "208--216",
journal = "Current Opinion in Structural Biology",
issn = "0959-440X",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Structure, function and evolution of multidomain proteins

AU - Vogel, Christine

AU - Bashton, Matthew

AU - Kerrison, Nicola D.

AU - Chothia, Cyrus

AU - Teichmann, Sarah A.

PY - 2004/4

Y1 - 2004/4

N2 - Proteins are composed of evolutionary units called domains; the majority of proteins consist of at least two domains. These domains and nature of their interactions determine the function of the protein. The roles that combinations of domains play in the formation of the protein repertoire have been found by analysis of domain assignments to genome sequences. Additional findings on the geometry of domains have been gained from examination of three-dimensional protein structures. Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations.

AB - Proteins are composed of evolutionary units called domains; the majority of proteins consist of at least two domains. These domains and nature of their interactions determine the function of the protein. The roles that combinations of domains play in the formation of the protein repertoire have been found by analysis of domain assignments to genome sequences. Additional findings on the geometry of domains have been gained from examination of three-dimensional protein structures. Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations.

KW - PDB

KW - Protein Data Bank

KW - RMSD

KW - Root mean square deviation

KW - SCOP

KW - SH

KW - Src homology

KW - Structural Classification of Proteins

KW - WHD

KW - Winged helix domain

UR - http://www.scopus.com/inward/record.url?scp=1842861592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842861592&partnerID=8YFLogxK

U2 - 10.1016/j.sbi.2004.03.011

DO - 10.1016/j.sbi.2004.03.011

M3 - Article

VL - 14

SP - 208

EP - 216

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

SN - 0959-440X

IS - 2

ER -