Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

Matthew P. Glenn, Sung Youn Chang, Oliver Hucke, Christophe L M J Verlinde, Kasey Rivas, Carrie Hornéy, Kohei Yokoyama, Frederick S. Buckner, Prakash R. Pendyala, Debopam Chakrabarti, Michael Gelb, Wesley C. Van Voorhis, Saïd M. Sebti, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) Antimalarial compounds: Structurally simple acyclic inhibitors of protein farnesyltransferase (active-site model shown) from the malaria parasite Plasmodium falciparum may allow third world countries access to an effective and inexpensive antimalarial therapy to counter the estimated half billion infections that occur annually.

Original languageEnglish (US)
Pages (from-to)4903-4906
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number31
DOIs
StatePublished - Aug 5 2005

Fingerprint

Farnesyltranstransferase
Antimalarials
Parasites
p21(ras) farnesyl-protein transferase

Keywords

  • Design
  • Drug
  • Enzymes
  • Inhibitors
  • Malaria
  • Medicinal chemistry

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. / Glenn, Matthew P.; Chang, Sung Youn; Hucke, Oliver; Verlinde, Christophe L M J; Rivas, Kasey; Hornéy, Carrie; Yokoyama, Kohei; Buckner, Frederick S.; Pendyala, Prakash R.; Chakrabarti, Debopam; Gelb, Michael; Van Voorhis, Wesley C.; Sebti, Saïd M.; Hamilton, Andrew.

In: Angewandte Chemie - International Edition, Vol. 44, No. 31, 05.08.2005, p. 4903-4906.

Research output: Contribution to journalArticle

Glenn, MP, Chang, SY, Hucke, O, Verlinde, CLMJ, Rivas, K, Hornéy, C, Yokoyama, K, Buckner, FS, Pendyala, PR, Chakrabarti, D, Gelb, M, Van Voorhis, WC, Sebti, SM & Hamilton, A 2005, 'Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites', Angewandte Chemie - International Edition, vol. 44, no. 31, pp. 4903-4906. https://doi.org/10.1002/anie.200500674
Glenn, Matthew P. ; Chang, Sung Youn ; Hucke, Oliver ; Verlinde, Christophe L M J ; Rivas, Kasey ; Hornéy, Carrie ; Yokoyama, Kohei ; Buckner, Frederick S. ; Pendyala, Prakash R. ; Chakrabarti, Debopam ; Gelb, Michael ; Van Voorhis, Wesley C. ; Sebti, Saïd M. ; Hamilton, Andrew. / Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. In: Angewandte Chemie - International Edition. 2005 ; Vol. 44, No. 31. pp. 4903-4906.
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