Structural plasticity and memory

Raphael Lamprecht, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

Much evidence indicates that, after learning, memories are created by alterations in glutamate-dependent excitatory synaptic transmission. These modifications are then actively stabilized, over hours or days, by structural changes at postsynaptic sites on dendritic spines. The mechanisms of this structural plasticity are poorly understood, but recent findings are beginning to provide clues. The changes in synaptic transmission are initiated by elevations in intracellular calcium and consequent activation of second messenger signalling pathways in the postsynaptic neuron. These pathways involve intracellular kinases and GTPases, downstream from glutamate receptors, that regulate and coordinate both cytoskeletal and adhesion remodelling, leading to new synaptic connections. Rapid changes in cytoskeletal and adhesion molecules after learning contribute to short-term plasticity and memory, whereas later changes, which depend on de novo protein synthesis as well as the early modifications, seem to be required for the persistence of long-term memory.

Original languageEnglish (US)
Pages (from-to)45-54
Number of pages10
JournalNature Reviews Neuroscience
Volume5
Issue number1
StatePublished - Jan 2004

Fingerprint

Synaptic Transmission
Learning
Dendritic Spines
Long-Term Memory
GTP Phosphohydrolases
Glutamate Receptors
Second Messenger Systems
Short-Term Memory
Glutamic Acid
Phosphotransferases
Calcium
Neurons
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Neuroscience(all)

Cite this

Structural plasticity and memory. / Lamprecht, Raphael; Ledoux, Joseph.

In: Nature Reviews Neuroscience, Vol. 5, No. 1, 01.2004, p. 45-54.

Research output: Contribution to journalArticle

Lamprecht, R & Ledoux, J 2004, 'Structural plasticity and memory', Nature Reviews Neuroscience, vol. 5, no. 1, pp. 45-54.
Lamprecht, Raphael ; Ledoux, Joseph. / Structural plasticity and memory. In: Nature Reviews Neuroscience. 2004 ; Vol. 5, No. 1. pp. 45-54.
@article{64da5b79baa4402daf7745640ca6b5cd,
title = "Structural plasticity and memory",
abstract = "Much evidence indicates that, after learning, memories are created by alterations in glutamate-dependent excitatory synaptic transmission. These modifications are then actively stabilized, over hours or days, by structural changes at postsynaptic sites on dendritic spines. The mechanisms of this structural plasticity are poorly understood, but recent findings are beginning to provide clues. The changes in synaptic transmission are initiated by elevations in intracellular calcium and consequent activation of second messenger signalling pathways in the postsynaptic neuron. These pathways involve intracellular kinases and GTPases, downstream from glutamate receptors, that regulate and coordinate both cytoskeletal and adhesion remodelling, leading to new synaptic connections. Rapid changes in cytoskeletal and adhesion molecules after learning contribute to short-term plasticity and memory, whereas later changes, which depend on de novo protein synthesis as well as the early modifications, seem to be required for the persistence of long-term memory.",
author = "Raphael Lamprecht and Joseph Ledoux",
year = "2004",
month = "1",
language = "English (US)",
volume = "5",
pages = "45--54",
journal = "Nature Reviews Neuroscience",
issn = "1471-003X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Structural plasticity and memory

AU - Lamprecht, Raphael

AU - Ledoux, Joseph

PY - 2004/1

Y1 - 2004/1

N2 - Much evidence indicates that, after learning, memories are created by alterations in glutamate-dependent excitatory synaptic transmission. These modifications are then actively stabilized, over hours or days, by structural changes at postsynaptic sites on dendritic spines. The mechanisms of this structural plasticity are poorly understood, but recent findings are beginning to provide clues. The changes in synaptic transmission are initiated by elevations in intracellular calcium and consequent activation of second messenger signalling pathways in the postsynaptic neuron. These pathways involve intracellular kinases and GTPases, downstream from glutamate receptors, that regulate and coordinate both cytoskeletal and adhesion remodelling, leading to new synaptic connections. Rapid changes in cytoskeletal and adhesion molecules after learning contribute to short-term plasticity and memory, whereas later changes, which depend on de novo protein synthesis as well as the early modifications, seem to be required for the persistence of long-term memory.

AB - Much evidence indicates that, after learning, memories are created by alterations in glutamate-dependent excitatory synaptic transmission. These modifications are then actively stabilized, over hours or days, by structural changes at postsynaptic sites on dendritic spines. The mechanisms of this structural plasticity are poorly understood, but recent findings are beginning to provide clues. The changes in synaptic transmission are initiated by elevations in intracellular calcium and consequent activation of second messenger signalling pathways in the postsynaptic neuron. These pathways involve intracellular kinases and GTPases, downstream from glutamate receptors, that regulate and coordinate both cytoskeletal and adhesion remodelling, leading to new synaptic connections. Rapid changes in cytoskeletal and adhesion molecules after learning contribute to short-term plasticity and memory, whereas later changes, which depend on de novo protein synthesis as well as the early modifications, seem to be required for the persistence of long-term memory.

UR - http://www.scopus.com/inward/record.url?scp=0347915731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347915731&partnerID=8YFLogxK

M3 - Article

C2 - 14708003

AN - SCOPUS:0347915731

VL - 5

SP - 45

EP - 54

JO - Nature Reviews Neuroscience

JF - Nature Reviews Neuroscience

SN - 1471-003X

IS - 1

ER -