Structural and radiometric asymmetry in brain images

Sarang Joshi, Peter Lorenzen, Guido Gerig, Elizabeth Bullitt

    Research output: Contribution to journalArticle

    Abstract

    This paper presents a general framework for analyzing structural and radiometric asymmetry in brain images. In a healthy brain, the left and right hemispheres are largely symmetric across the mid-sagittal plane. Brain tumors may belong to one or both of the following categories: mass-effect, in which the diseased tissue displaces healthy tissue; and infiltrating, in which healthy tissue has become diseased. Mass-effect brain tumors cause structural asymmetry by displacing healthy tissue, and may cause radiometric asymmetry in adjacent normal structures due to edema. Infiltrating tumors have a different radiometric response from healthy tissue. Thus, structural and radiometric asymmetries across the mid-sagittal plane in brain images provide important cues that tumors may be present. We have developed a framework that registers images with their reflections across the mid-sagittal plane. The registration process accounts for tissue displacement through large deformation image warping. Radiometric differences are taken into account through an additive intensity field. We present an efficient multi-scale algorithm for the joint estimation of structural and radiometric asymmetry. Results for nine MR images of patients with tumors and four normal control subjects are presented.

    Original languageEnglish (US)
    Pages (from-to)155-170
    Number of pages16
    JournalMedical Image Analysis
    Volume7
    Issue number2
    DOIs
    Publication statusPublished - Jun 2003

      Fingerprint

    Keywords

    • Brain symmetry analysis
    • Deformable image mapping
    • Medical image analysis
    • Plane of symmetry estimation

    ASJC Scopus subject areas

    • Computer Graphics and Computer-Aided Design
    • Computer Vision and Pattern Recognition
    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

    Cite this