Abstract
The ability of the infracallosal 5-HT axons to assume the function of the supracallosal 5-HT axons in restoring symmetry in turning behaviour suggests that the function performed by these fibres is not unique to either projection. This situation is similar to that found by Langley for autonomic nerve fibres in the peripheral nervous system. He concluded 'that the function of any autonomic nerve fibre depends not so much upon its inherent properties as upon the nerve cells with which it has an opportunity of becoming connected in the process of development'. Thus, the function of the serotoninergic nerve fibres in the central nervous system may depend on the inherent properties of the neural systems with which they connect. This could explain why manipulation of whole brain 5-HT influences such a large number of behaviours. For instance, 5-HT has been shown to be involved in the regulaton of sleep, temperature, pain, aggression, locomotor activity, self-stimulation, sexual behaviour, avoidance-learning and water consumption. Thus it is possible that any one of these behaviours may be selectively modulated by the localised manipulations of 5-HT within the brain structure subserving that particular behaviour.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 374-376 |
| Number of pages | 3 |
| Journal | Nature |
| Volume | 274 |
| Issue number | 5669 |
| State | Published - 1978 |
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Cite this
Structural and functional restoration by collateral sprouting of hippocampal 5-HT axons. / Azmitia, Efrain; Buchan, A. M.; Williams, J. H.
In: Nature, Vol. 274, No. 5669, 1978, p. 374-376.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structural and functional restoration by collateral sprouting of hippocampal 5-HT axons
AU - Azmitia, Efrain
AU - Buchan, A. M.
AU - Williams, J. H.
PY - 1978
Y1 - 1978
N2 - The ability of the infracallosal 5-HT axons to assume the function of the supracallosal 5-HT axons in restoring symmetry in turning behaviour suggests that the function performed by these fibres is not unique to either projection. This situation is similar to that found by Langley for autonomic nerve fibres in the peripheral nervous system. He concluded 'that the function of any autonomic nerve fibre depends not so much upon its inherent properties as upon the nerve cells with which it has an opportunity of becoming connected in the process of development'. Thus, the function of the serotoninergic nerve fibres in the central nervous system may depend on the inherent properties of the neural systems with which they connect. This could explain why manipulation of whole brain 5-HT influences such a large number of behaviours. For instance, 5-HT has been shown to be involved in the regulaton of sleep, temperature, pain, aggression, locomotor activity, self-stimulation, sexual behaviour, avoidance-learning and water consumption. Thus it is possible that any one of these behaviours may be selectively modulated by the localised manipulations of 5-HT within the brain structure subserving that particular behaviour.
AB - The ability of the infracallosal 5-HT axons to assume the function of the supracallosal 5-HT axons in restoring symmetry in turning behaviour suggests that the function performed by these fibres is not unique to either projection. This situation is similar to that found by Langley for autonomic nerve fibres in the peripheral nervous system. He concluded 'that the function of any autonomic nerve fibre depends not so much upon its inherent properties as upon the nerve cells with which it has an opportunity of becoming connected in the process of development'. Thus, the function of the serotoninergic nerve fibres in the central nervous system may depend on the inherent properties of the neural systems with which they connect. This could explain why manipulation of whole brain 5-HT influences such a large number of behaviours. For instance, 5-HT has been shown to be involved in the regulaton of sleep, temperature, pain, aggression, locomotor activity, self-stimulation, sexual behaviour, avoidance-learning and water consumption. Thus it is possible that any one of these behaviours may be selectively modulated by the localised manipulations of 5-HT within the brain structure subserving that particular behaviour.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018099809&partnerID=8YFLogxK
M3 - Article
C2 - 566855
AN - SCOPUS:0018099809
VL - 274
SP - 374
EP - 376
JO - Nature Cell Biology
JF - Nature Cell Biology
SN - 1465-7392
IS - 5669
ER -