Stress and the trade-off between hippocampal and striatal memory

Elizabeth V. Goldfarb, Elizabeth Phelps

Research output: Contribution to journalReview article

Abstract

Stress can strongly influence memory, in part by modulating the relative engagement of multiple memory systems. Over the last fifteen years, researchers have demonstrated that stress leads striatal, rather than hippocampal, memory to be dominant in both humans and non-human animals. This shift has been proposed to explain the etiology and maintenance of symptoms of stress-related psychopathology. However, it remains unclear how hippocampal and striatal memory are affected individually in order to facilitate this trade-off. Recent studies provide empirical support for (at least) three different pathways by which stress could modulate these memory systems. Evidence for these diverse effects of stress, and circumstances under which each might occur, are discussed.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalCurrent Opinion in Behavioral Sciences
Volume14
DOIs
StatePublished - Apr 1 2017

Fingerprint

Corpus Striatum
Psychopathology
Maintenance
Research Personnel

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Stress and the trade-off between hippocampal and striatal memory. / Goldfarb, Elizabeth V.; Phelps, Elizabeth.

In: Current Opinion in Behavioral Sciences, Vol. 14, 01.04.2017, p. 47-53.

Research output: Contribution to journalReview article

@article{674cb5d18a2b499b923f51849cd84bc3,
title = "Stress and the trade-off between hippocampal and striatal memory",
abstract = "Stress can strongly influence memory, in part by modulating the relative engagement of multiple memory systems. Over the last fifteen years, researchers have demonstrated that stress leads striatal, rather than hippocampal, memory to be dominant in both humans and non-human animals. This shift has been proposed to explain the etiology and maintenance of symptoms of stress-related psychopathology. However, it remains unclear how hippocampal and striatal memory are affected individually in order to facilitate this trade-off. Recent studies provide empirical support for (at least) three different pathways by which stress could modulate these memory systems. Evidence for these diverse effects of stress, and circumstances under which each might occur, are discussed.",
author = "Goldfarb, {Elizabeth V.} and Elizabeth Phelps",
year = "2017",
month = "4",
day = "1",
doi = "10.1016/j.cobeha.2016.11.017",
language = "English (US)",
volume = "14",
pages = "47--53",
journal = "Current Opinion in Behavioral Sciences",
issn = "2352-1546",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Stress and the trade-off between hippocampal and striatal memory

AU - Goldfarb, Elizabeth V.

AU - Phelps, Elizabeth

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Stress can strongly influence memory, in part by modulating the relative engagement of multiple memory systems. Over the last fifteen years, researchers have demonstrated that stress leads striatal, rather than hippocampal, memory to be dominant in both humans and non-human animals. This shift has been proposed to explain the etiology and maintenance of symptoms of stress-related psychopathology. However, it remains unclear how hippocampal and striatal memory are affected individually in order to facilitate this trade-off. Recent studies provide empirical support for (at least) three different pathways by which stress could modulate these memory systems. Evidence for these diverse effects of stress, and circumstances under which each might occur, are discussed.

AB - Stress can strongly influence memory, in part by modulating the relative engagement of multiple memory systems. Over the last fifteen years, researchers have demonstrated that stress leads striatal, rather than hippocampal, memory to be dominant in both humans and non-human animals. This shift has been proposed to explain the etiology and maintenance of symptoms of stress-related psychopathology. However, it remains unclear how hippocampal and striatal memory are affected individually in order to facilitate this trade-off. Recent studies provide empirical support for (at least) three different pathways by which stress could modulate these memory systems. Evidence for these diverse effects of stress, and circumstances under which each might occur, are discussed.

UR - http://www.scopus.com/inward/record.url?scp=85006959013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006959013&partnerID=8YFLogxK

U2 - 10.1016/j.cobeha.2016.11.017

DO - 10.1016/j.cobeha.2016.11.017

M3 - Review article

AN - SCOPUS:85006959013

VL - 14

SP - 47

EP - 53

JO - Current Opinion in Behavioral Sciences

JF - Current Opinion in Behavioral Sciences

SN - 2352-1546

ER -