Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Jessica J. Walsh, Allyson K. Friedman, Haosheng Sun, Elizabeth A. Heller, Stacy M. Ku, Barbara Juarez, Veronica L. Burnham, Michelle S. Mazei-Robison, Deveroux Ferguson, Sam A. Golden, Ja Wook Koo, Dipesh Chaudhury, Daniel J. Christoffel, Lisa Pomeranz, Jeffrey M. Friedman, Scott J. Russo, Eric J. Nestler, Ming Hu Han

Research output: Contribution to journalArticle

Abstract

Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
JournalNature Neuroscience
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Corticotropin-Releasing Hormone
Brain-Derived Neurotrophic Factor
Reward
Nucleus Accumbens
Optogenetics
Dopamine
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., ... Han, M. H. (2014). Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nature Neuroscience, 17(1), 27-29. https://doi.org/10.1038/nn.3591

Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. / Walsh, Jessica J.; Friedman, Allyson K.; Sun, Haosheng; Heller, Elizabeth A.; Ku, Stacy M.; Juarez, Barbara; Burnham, Veronica L.; Mazei-Robison, Michelle S.; Ferguson, Deveroux; Golden, Sam A.; Koo, Ja Wook; Chaudhury, Dipesh; Christoffel, Daniel J.; Pomeranz, Lisa; Friedman, Jeffrey M.; Russo, Scott J.; Nestler, Eric J.; Han, Ming Hu.

In: Nature Neuroscience, Vol. 17, No. 1, 01.01.2014, p. 27-29.

Research output: Contribution to journalArticle

Walsh, JJ, Friedman, AK, Sun, H, Heller, EA, Ku, SM, Juarez, B, Burnham, VL, Mazei-Robison, MS, Ferguson, D, Golden, SA, Koo, JW, Chaudhury, D, Christoffel, DJ, Pomeranz, L, Friedman, JM, Russo, SJ, Nestler, EJ & Han, MH 2014, 'Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway', Nature Neuroscience, vol. 17, no. 1, pp. 27-29. https://doi.org/10.1038/nn.3591
Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B et al. Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nature Neuroscience. 2014 Jan 1;17(1):27-29. https://doi.org/10.1038/nn.3591
Walsh, Jessica J. ; Friedman, Allyson K. ; Sun, Haosheng ; Heller, Elizabeth A. ; Ku, Stacy M. ; Juarez, Barbara ; Burnham, Veronica L. ; Mazei-Robison, Michelle S. ; Ferguson, Deveroux ; Golden, Sam A. ; Koo, Ja Wook ; Chaudhury, Dipesh ; Christoffel, Daniel J. ; Pomeranz, Lisa ; Friedman, Jeffrey M. ; Russo, Scott J. ; Nestler, Eric J. ; Han, Ming Hu. / Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. In: Nature Neuroscience. 2014 ; Vol. 17, No. 1. pp. 27-29.
@article{5c8c4bb989c3475c94ebc0771959f606,
title = "Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway",
abstract = "Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.",
author = "Walsh, {Jessica J.} and Friedman, {Allyson K.} and Haosheng Sun and Heller, {Elizabeth A.} and Ku, {Stacy M.} and Barbara Juarez and Burnham, {Veronica L.} and Mazei-Robison, {Michelle S.} and Deveroux Ferguson and Golden, {Sam A.} and Koo, {Ja Wook} and Dipesh Chaudhury and Christoffel, {Daniel J.} and Lisa Pomeranz and Friedman, {Jeffrey M.} and Russo, {Scott J.} and Nestler, {Eric J.} and Han, {Ming Hu}",
year = "2014",
month = "1",
day = "1",
doi = "10.1038/nn.3591",
language = "English (US)",
volume = "17",
pages = "27--29",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

AU - Walsh, Jessica J.

AU - Friedman, Allyson K.

AU - Sun, Haosheng

AU - Heller, Elizabeth A.

AU - Ku, Stacy M.

AU - Juarez, Barbara

AU - Burnham, Veronica L.

AU - Mazei-Robison, Michelle S.

AU - Ferguson, Deveroux

AU - Golden, Sam A.

AU - Koo, Ja Wook

AU - Chaudhury, Dipesh

AU - Christoffel, Daniel J.

AU - Pomeranz, Lisa

AU - Friedman, Jeffrey M.

AU - Russo, Scott J.

AU - Nestler, Eric J.

AU - Han, Ming Hu

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.

AB - Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.

UR - http://www.scopus.com/inward/record.url?scp=84893713925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893713925&partnerID=8YFLogxK

U2 - 10.1038/nn.3591

DO - 10.1038/nn.3591

M3 - Article

VL - 17

SP - 27

EP - 29

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 1

ER -