Strain difference in fear between spontaneously hypertensive and normotensive rats is mediated by adrenal cortical hormones

Akira Sakaguchi, Joseph Ledoux, Alan F. Sved, Donald J. Reis

Research output: Contribution to journalArticle

Abstract

In the present study we sought to determine whether the strain difference in fear reactivity between spontaneously hypertensive rats (SHR) and strain-matched WKY controls might be related to adrenocortical function. SHR and WKY were subjected to adrenalectomy prior to classical fear conditioning. Adrenal cortical steroids were replaced in some animals. Adrenalectomy produced comparable effects on conditioned fear reactivity in SHR and WKY and steroid replacement reversed the effects of adrenalectomy in both strains. However, a larger dose was required to compensate for adrenalectomy in SHR. These date implicate functions related, directly or indirectly, to the adrenal cortex, in the maintenance of the strain difference in fear reactivity.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalNeuroscience Letters
Volume46
Issue number1
DOIs
StatePublished - Apr 20 1984

Fingerprint

Adrenalectomy
Inbred SHR Rats
Fear
Hormones
Steroids
Classical Conditioning
Adrenal Cortex
Maintenance

Keywords

  • adrenal cortex
  • classical conditioning
  • corticosterone
  • fear
  • spontaneously hypertensive rats
  • strain differences

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Strain difference in fear between spontaneously hypertensive and normotensive rats is mediated by adrenal cortical hormones. / Sakaguchi, Akira; Ledoux, Joseph; Sved, Alan F.; Reis, Donald J.

In: Neuroscience Letters, Vol. 46, No. 1, 20.04.1984, p. 59-64.

Research output: Contribution to journalArticle

@article{4b05451c4c7d465aaace8318b0587599,
title = "Strain difference in fear between spontaneously hypertensive and normotensive rats is mediated by adrenal cortical hormones",
abstract = "In the present study we sought to determine whether the strain difference in fear reactivity between spontaneously hypertensive rats (SHR) and strain-matched WKY controls might be related to adrenocortical function. SHR and WKY were subjected to adrenalectomy prior to classical fear conditioning. Adrenal cortical steroids were replaced in some animals. Adrenalectomy produced comparable effects on conditioned fear reactivity in SHR and WKY and steroid replacement reversed the effects of adrenalectomy in both strains. However, a larger dose was required to compensate for adrenalectomy in SHR. These date implicate functions related, directly or indirectly, to the adrenal cortex, in the maintenance of the strain difference in fear reactivity.",
keywords = "adrenal cortex, classical conditioning, corticosterone, fear, spontaneously hypertensive rats, strain differences",
author = "Akira Sakaguchi and Joseph Ledoux and Sved, {Alan F.} and Reis, {Donald J.}",
year = "1984",
month = "4",
day = "20",
doi = "10.1016/0304-3940(84)90199-X",
language = "English (US)",
volume = "46",
pages = "59--64",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Strain difference in fear between spontaneously hypertensive and normotensive rats is mediated by adrenal cortical hormones

AU - Sakaguchi, Akira

AU - Ledoux, Joseph

AU - Sved, Alan F.

AU - Reis, Donald J.

PY - 1984/4/20

Y1 - 1984/4/20

N2 - In the present study we sought to determine whether the strain difference in fear reactivity between spontaneously hypertensive rats (SHR) and strain-matched WKY controls might be related to adrenocortical function. SHR and WKY were subjected to adrenalectomy prior to classical fear conditioning. Adrenal cortical steroids were replaced in some animals. Adrenalectomy produced comparable effects on conditioned fear reactivity in SHR and WKY and steroid replacement reversed the effects of adrenalectomy in both strains. However, a larger dose was required to compensate for adrenalectomy in SHR. These date implicate functions related, directly or indirectly, to the adrenal cortex, in the maintenance of the strain difference in fear reactivity.

AB - In the present study we sought to determine whether the strain difference in fear reactivity between spontaneously hypertensive rats (SHR) and strain-matched WKY controls might be related to adrenocortical function. SHR and WKY were subjected to adrenalectomy prior to classical fear conditioning. Adrenal cortical steroids were replaced in some animals. Adrenalectomy produced comparable effects on conditioned fear reactivity in SHR and WKY and steroid replacement reversed the effects of adrenalectomy in both strains. However, a larger dose was required to compensate for adrenalectomy in SHR. These date implicate functions related, directly or indirectly, to the adrenal cortex, in the maintenance of the strain difference in fear reactivity.

KW - adrenal cortex

KW - classical conditioning

KW - corticosterone

KW - fear

KW - spontaneously hypertensive rats

KW - strain differences

UR - http://www.scopus.com/inward/record.url?scp=0021322043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021322043&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(84)90199-X

DO - 10.1016/0304-3940(84)90199-X

M3 - Article

C2 - 6728330

AN - SCOPUS:0021322043

VL - 46

SP - 59

EP - 64

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -