Stochastic spineless expression creates the retinal mosaic for colour vision

Mathias F. Wernet, Esteban O. Mazzoni, Arzu Çelik, Dianne M. Duncan, Ian Duncan, Claude Desplan

Research output: Contribution to journalArticle

Abstract

Drosophila colour vision is achieved by R7 and R8 photoreceptor cells present in every ommatidium. The fly retina contains two types of ommatidia, called 'pale' and 'yellow', defined by different rhodopsin pairs expressed in R7 and R8 cells. Similar to the human cone photoreceptors, these ommatidial subtypes are distributed stochastically in the retina. The choice between pale versus yellow ommatidia is made in R7 cells, which then impose their fate onto R8. Here we report that the Drosophila dioxin receptor Spineless is both necessary and sufficient for the formation of the ommatidial mosaic. A short burst of spineless expression at mid-pupation in a large subset of R7 cells precedes rhodopsin expression. In spineless mutants, all R7 and most R8 cells adopt the pale fate, whereas overexpression of spineless is sufficient to induce the yellow R7 fate. Therefore, this study suggests that the entire retinal mosaic required for colour vision is defined by the stochastic expression of a single transcription factor, Spineless.

Original languageEnglish (US)
Pages (from-to)174-180
Number of pages7
JournalNature
Volume440
Issue number7081
DOIs
StatePublished - Mar 9 2006

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Color Vision
Rhodopsin
Drosophila
Retina
Retinal Cone Photoreceptor Cells
Aryl Hydrocarbon Receptors
Photoreceptor Cells
Diptera
Transcription Factors

ASJC Scopus subject areas

  • General

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Stochastic spineless expression creates the retinal mosaic for colour vision. / Wernet, Mathias F.; Mazzoni, Esteban O.; Çelik, Arzu; Duncan, Dianne M.; Duncan, Ian; Desplan, Claude.

In: Nature, Vol. 440, No. 7081, 09.03.2006, p. 174-180.

Research output: Contribution to journalArticle

Wernet, Mathias F. ; Mazzoni, Esteban O. ; Çelik, Arzu ; Duncan, Dianne M. ; Duncan, Ian ; Desplan, Claude. / Stochastic spineless expression creates the retinal mosaic for colour vision. In: Nature. 2006 ; Vol. 440, No. 7081. pp. 174-180.
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