Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones

J. A. Hamilton, S. R. Lingelbach, Nicola Partridge, T. J. Martin

Research output: Contribution to journalArticle

Abstract

Hormonal control of plasminogen activator (PA) was studied in clonal rat osteogenic sarcoma cells which are phenotypically osteoblast, and in osteoblast-rich rat bone cell cultures. The bone-resorbing hormones (parathyroid hormone, prostaglandin E2, epidermal growth factor and 1,25-dihydroxyvitamin D3) stimulated PA activity in both cell types. The relative efficacies of vitamin D metabolites and of prostanoids reflect their relative potencies as stimulators of bone resorption.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume122
Issue number1
DOIs
StatePublished - Jul 18 1984

Fingerprint

Plasminogen Activators
Osteoblasts
Bone
Hormones
Bone and Bones
Rats
Calcitriol
Osteosarcoma
Bone Resorption
Parathyroid Hormone
Dinoprostone
Epidermal Growth Factor
Vitamin D
Prostaglandins
Cell Culture Techniques
Metabolites
Cell culture

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones. / Hamilton, J. A.; Lingelbach, S. R.; Partridge, Nicola; Martin, T. J.

In: Biochemical and Biophysical Research Communications, Vol. 122, No. 1, 18.07.1984, p. 230-236.

Research output: Contribution to journalArticle

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