Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones

J. A. Hamilton, S. R. Lingelbach, N. C. Partridge, T. J. Martin

Research output: Contribution to journalArticle


Hormonal control of plasminogen activator (PA) was studied in clonal rat osteogenic sarcoma cells which are phenotypically osteoblast, and in osteoblast-rich rat bone cell cultures. The bone-resorbing hormones (parathyroid hormone, prostaglandin E2, epidermal growth factor and 1,25-dihydroxyvitamin D3) stimulated PA activity in both cell types. The relative efficacies of vitamin D metabolites and of prostanoids reflect their relative potencies as stimulators of bone resorption.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Jul 18 1984


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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