Stimulation of DNA synthesis in mouse pancreas by triiodothyronine and glucagon

Daniel Malamud, L. Perrin

Research output: Contribution to journalArticle

Abstract

An injection of triiodothyronine and glucagon stimulates the growth of several mouse tissues. The greatest increase in DNA specific activity occurred in the cells of the exocrine pancreas after a lag period of about 30 hr. There was also an increase in cell proliferation in the liver. Cellular hypertrophy, as measured by the ratio of RNA to DNA was increased in liver and kidney. This system should prove to be particularly useful for studying the factors controlling pancreatic growth.

Original languageEnglish (US)
Pages (from-to)1157-1160
Number of pages4
JournalEndocrinology
Volume94
Issue number4
StatePublished - 1974

Fingerprint

Triiodothyronine
Glucagon
Pancreas
Exocrine Pancreas
Liver
DNA
Growth
Hypertrophy
Cell Proliferation
RNA
Kidney
Injections

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Stimulation of DNA synthesis in mouse pancreas by triiodothyronine and glucagon. / Malamud, Daniel; Perrin, L.

In: Endocrinology, Vol. 94, No. 4, 1974, p. 1157-1160.

Research output: Contribution to journalArticle

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