Stereoselective total syntheses of herbicidin C and aureonuclemycin through late-stage glycosylation

Dominik Hager, Peter Mayer, Christian Paulitz, Jörg Tiebes, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

Better late than never! Two herbicidins, members of an important family of nucleoside antibiotics, have been synthesized for the first time. The route integrates a stereoselective C-glycosylation with several reagent-controlled stereoselective transformations and a surprisingly facile and highly diastereoselective late-stage N-glycosylation.

Original languageEnglish (US)
Pages (from-to)6525-6528
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number26
DOIs
StatePublished - Jun 25 2012

Fingerprint

Glycosylation
Antibiotics
Nucleosides
Anti-Bacterial Agents
herbicidin C
herbicidins

Keywords

  • antibiotics
  • glycosylation
  • nucleosides
  • stereoselective synthesis
  • total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Stereoselective total syntheses of herbicidin C and aureonuclemycin through late-stage glycosylation. / Hager, Dominik; Mayer, Peter; Paulitz, Christian; Tiebes, Jörg; Trauner, Dirk.

In: Angewandte Chemie - International Edition, Vol. 51, No. 26, 25.06.2012, p. 6525-6528.

Research output: Contribution to journalArticle

Hager, Dominik ; Mayer, Peter ; Paulitz, Christian ; Tiebes, Jörg ; Trauner, Dirk. / Stereoselective total syntheses of herbicidin C and aureonuclemycin through late-stage glycosylation. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 26. pp. 6525-6528.
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