Stereoselective synthesis of substituted γ-butyrolactones by the [3 + 2] annulation of allylic silanes with chlorosulfonyl isocyanate

Enantioselective total synthesis of (+)-blastmycinone

Zhi Hui Peng, Keith Woerpel

Research output: Contribution to journalArticle

Abstract

Equation presented (+)-blastmycinone A stereoselective synthesis of γ-butyrolactones by the [3 + 2] annulation of allylic silanes with N-chlorosulfonyl isocyanate (CSI) was developed. An enantioselective total synthesis of (+)-blastmycinone was accomplished using this annulation as the key step.

Original languageEnglish (US)
Pages (from-to)675-678
Number of pages4
JournalOrganic Letters
Volume3
Issue number5
DOIs
StatePublished - Mar 8 2001

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Silanes
isocyanates
silanes
synthesis
blastomycinone
chlorosulfonyl isocyanate
N-chlorosulfonyl isocyanate

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

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abstract = "Equation presented (+)-blastmycinone A stereoselective synthesis of γ-butyrolactones by the [3 + 2] annulation of allylic silanes with N-chlorosulfonyl isocyanate (CSI) was developed. An enantioselective total synthesis of (+)-blastmycinone was accomplished using this annulation as the key step.",
author = "Peng, {Zhi Hui} and Keith Woerpel",
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AU - Peng, Zhi Hui

AU - Woerpel, Keith

PY - 2001/3/8

Y1 - 2001/3/8

N2 - Equation presented (+)-blastmycinone A stereoselective synthesis of γ-butyrolactones by the [3 + 2] annulation of allylic silanes with N-chlorosulfonyl isocyanate (CSI) was developed. An enantioselective total synthesis of (+)-blastmycinone was accomplished using this annulation as the key step.

AB - Equation presented (+)-blastmycinone A stereoselective synthesis of γ-butyrolactones by the [3 + 2] annulation of allylic silanes with N-chlorosulfonyl isocyanate (CSI) was developed. An enantioselective total synthesis of (+)-blastmycinone was accomplished using this annulation as the key step.

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